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Imaging of Epidermal Growth Factor Receptor Expression in Head and Neck Cancer with SPECT/CT and 111In-Labeled Cetuximab-F(ab′)2
TLDR
The 111In-cetuximab-F(ab′)2 tracer to image EGFR targeting in vivo displays higher tumor-to-blood ratios early after injection than 111 in an HNSCC model, making it more suitable for EGFR visualization and potentially for selecting patients for treatment with EGFR inhibitors. Expand
ImmunoSPECT and ImmunoPET of IGF-1R Expression with the Radiolabeled Antibody R1507 in a Triple-Negative Breast Cancer Model
TLDR
111In-R 1507 and 89Zr-R1507 are new tracers to noninvasively determine IGF-1R expression in vivo in breast cancer xenografts using SPECT and PET, and in the future, these techniques may enable patient selection for IGF- 1R–targeted therapy. Expand
PET of Hypoxia with 89Zr-Labeled cG250-F(ab′)2 in Head and Neck Tumors
TLDR
Investigation of whether 89Zr-labeled cG250-F(ab′)2 allowed visualization of tumor hypoxia using small-animal PET and whether the tracer showed spatial correlation to the microscopic distribution of CAIX-expressing cells in a human head and neck xenograft tumor model showed rapid accumulation. Expand
Development of an imaging-guided CEA-pretargeted radionuclide treatment of advanced colorectal cancer: first clinical results
TLDR
This phase I study demonstrates for the first time that pretargeting with bsMAb TF2 and radiolabelled IMP288 in patients with CEA-expressing CRC is feasible and safe. Expand
68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms
TLDR
The comparison of specificity towards different microorganisms and human lung cancer cells (H1299) is reported on to show that 68Ga-TAFC and 68 Ga-FOXE have high uptake in A. fumigatus both in vitro and in vivo. Expand
PET of Tumors Expressing Gastrin-Releasing Peptide Receptor with an 18F-Labeled Bombesin Analog
TLDR
A NotA-conjugated bombesin derivative, NOTA-8-Aoc-BBN(7-14)NH2, could be labeled rapidly and efficiently with 18F using a 1-pot, 1-step method and demonstrated GRPR-binding specificity, which was demonstrated by reduced tumor uptake of radiolabeled NOTA. Expand
Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent
TLDR
The preclinical application of PSMA I&T, a DOTAGA-chelated urea-based PSMA inhibitor, for SPECT/CT imaging and radionuclide therapy of prostate cancer is presented and indicates that PSMA-specific uptake in kidneys can be successfully tackled using blocking agents such as 2-PMPA. Expand
Dual-Modality Image-Guided Surgery of Prostate Cancer with a Radiolabeled Fluorescent Anti-PSMA Monoclonal Antibody
TLDR
Dual-labeled 111In-DTPA-D2B-IRDye800CW enables specific and sensitive detection of prostate cancer lesions in vivo with micro-SPECT/CT and NIRF imaging and enables image-guided surgical resection. Expand
Targeting human prostate cancer with 111In-labeled D2B IgG, F(ab')2 and Fab fragments in nude mice with PSMA-expressing xenografts.
TLDR
The feasibility of D2B IgG, F(ab')2 and Fab fragments for targeting PSMA-expressing prostate cancer xenografts is demonstrated, and the optimal time point for imaging was determined in biodistribution and microSPECT imaging studies. Expand
Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging
TLDR
Both compounds showed excellent pharmacokinetics, highly selective accumulation in infected lung tissue and good correlation with severity of disease in a rat infection model, which makes them promising agents for A. fumigatus infection imaging. Expand
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