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Pharmacokinetics of L-Carnitine
TLDR
The renal clearance of L-carnitine increases after exogenous administration, approaching GFR after high intravenous doses, and many forms of secondary carnitine deficiency, including some drug-induced disorders, arise from impaired renal tubular re absorption. Expand
Pharmacokinetics of L‐carnitine in patients with end‐stage renal disease undergoing long‐term hemodialysis
TLDR
Evaluated the pharmacokinetics of intravenous L‐carnitine in patients undergoing long‐term hemodialysis to find out if it can be administered to restore plasma and tissue levels. Expand
Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis.
TLDR
TMA and TMNO accumulate between haemodialysis sessions in ESRD patients, but are efficiently removed during a single haemmodialysis session. Expand
Impact of hemodialysis on endogenous plasma and muscle carnitine levels in patients with end-stage renal disease.
TLDR
Long-term hemodialysis treatment is associated with a significant reduction in endogenous plasma and muscle L-c Carnitine levels and a significant increase in plasma acylcarnitines, while muscle levels continue to decline after 12 months of treatment. Expand
Trimethylamine: metabolic, pharmacokinetic and safety aspects.
TLDR
Trimethylaminuria is a condition that is characterized by a deficiency in FMO3 enzyme activity, resulting in the excretion of increased amounts of TMA in bodily fluids such as urine and sweat, and breath. Expand
Impact of haemodialysis on individual endogenous plasma acylcarnitine concentrations in end-stage renal disease
TLDR
The accumulation of acylcarnitines during long-term haemodialysis suggests that removal by haemmodialysis is less efficient than removal from the body by the healthy kidney. Expand
Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers.
TLDR
The administration of Spedifen resulted in very rapid absorption of the (+)S-isomer (eutomer) with tmax values much lower than those observed for this isomer when conventional oral solid formulations such as capsules or tablets of racemic ibuprofen are administered. Expand
The use of pharmacoscintigraphy to focus the development strategy for a novel 5-ASA colon targeting system (TIME CLOCK® system)
TLDR
The pharmacoscintigraphic findings provide “proof of concept” data for the colonic delivery of 5-ASA using enteric coated “TIME CLOCK®” technology and help focus the development strategy for subsequent clinical studies in the patient population. Expand
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