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Dopamine visualized in the basal ganglia of living man
The neurotransmitter dopamine has biological attributes that make it amenable to study by positron emission tomography, unlike many of the 40 or so neurotransmitters that have been identified in theExpand
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Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography.
L-[18F] fluorodopa was administered in trace amounts intravenously to healthy control subjects and to patients with Parkinson's disease. Striatal uptake of radioactivity was measured using positronExpand
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Cerebral Metabolism of 6–[18F]Fluoro‐l‐3,4‐Dihydroxyphenylalanine in the Primate
Abstract: The tracers 6‐[18F]fluoro‐1‐3,4‐dihydroxyphenyl‐alanine (6–[18F]fluoro‐l‐DOPA) and 1‐[14C]DOPA were injected simultaneously into rhesus monkeys, and the time course of their metabolites wasExpand
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A probe for intracerebral aromatic amino‐acid decarboxylase activity: Distribution and kinetics of [18F]6‐fluoro‐L‐m‐tyrosine in the human brain
Positron tomography, using [18F]6‐fluoro‐L‐dopa as a tracer, has been used for the study of Parkinson's disease. Unfortunately, the analysis of data obtained with this agent is bedeviled because itExpand
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Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia.
This study examines whether the duration of treatment with antipsychotic drugs influences the regional distribution of cerebral [18F]2-fluoro-2-deoxy-D-glucose utilization as measured by positronExpand
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The effects of beta(1)-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: A double-blind, placebo-controlled, positron-emission
BACKGROUND The mechanism for the beneficial effect of beta-blocker therapy in patients with left ventricular (LV) dysfunction is unclear, but it may relate to an energy-sparing effect that results inExpand
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Metabolites of 6-[18F]fluoro-L-dopa in human blood.
The metabolites of 6-[18F]fluoro-L-dopa in the blood plasma of healthy humans have been identified as 3-O-sulfato-6[18F]fluoro-L-dopa, 3-O-methyl-6-[18F]fluoro-L-dopa, 6-[18F] fluorodopamine, andExpand
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The Effects of β1-Blockade on Oxidative Metabolism and the Metabolic Cost of Ventricular Work in Patients With Left Ventricular Dysfunction
Background—The mechanism for the beneficial effect of β-blocker therapy in patients with left ventricular (LV) dysfunction is unclear, but it may relate to an energy-sparing effect that results inExpand
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Aromatic radiofluorination with [18F]fluorine gas: 6-[18F]fluoro-L-dopa.
A new synthesis is described for the routine production of 3,4-dihydroxy-6-[18F]fluoro-phenyl-L-alanine (6-[18F]fluoro-L-dopa). The reaction between [18F]fluorine gas andExpand
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Estimation of the radiation dose in man due to 6-[18F]fluoro-L-dopa.
The radiation dose to the organs of the human body after an intravenous administration of 6-[18F]fluoro-L-dopa was estimated using the recommendations of the International Committee on RadiologicalExpand
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