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Structure of the thermally stable Zika virus
Zika virus (ZIKV), formerly a neglected pathogen, has recently been associated with microcephaly in fetuses, and with Guillian–Barré syndrome in adults. Here we present the 3.7 Å resolutionExpand
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Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers
An antibody to lock dengue virus out Mosquito-borne dengue virus (DENV) is a growing public health threat. Nearly 400 million people are infected annually, and no vaccine is currently available.Expand
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A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins
Dengue virus (DENV) infects ~400 million people annually. There is no licensed vaccine or therapeutic drug. Only a small fraction of the total DENV-specific antibodies in a naturally occurring dengueExpand
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A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface
Dengue virus (DENV), which consists of four serotypes (DENV1‐4), infects over 400 million people annually. Previous studies have indicated most human monoclonal antibodies (HMAbs) from dengueExpand
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Structural Changes in Dengue Virus When Exposed to a Temperature of 37°C
ABSTRACT Previous binding studies of antibodies that recognized a partially or fully hidden epitope suggest that insect cell-derived dengue virus undergoes structural changes at an elevatedExpand
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A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential
Zika virus (ZIKV), a mosquito-borne flavivirus, causes devastating congenital birth defects. We isolated a human monoclonal antibody (mAb), ZKA190, that potently cross-neutralizes multi-lineage ZIKVExpand
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The development of therapeutic antibodies against dengue virus.
Dengue virus, a positive-sense RNA virus, is one of the major human pathogens transmitted by mosquitoes. However, no fully effective licensed dengue vaccines or therapeutics are currently available.Expand
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Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C
The ability of DENV2 to display different morphologies (hence different antigenic properties) complicates vaccine and therapeutics development. Previous studies showed most strains of laboratoryExpand
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Structural changes of dengue virus when exposed to 37 oC 1 2
2 Guntur Fibriansah, Thiam-Seng Ng, Victor A. Kostyuchenko, Jaime Lee, Sumarlin 3 Lee, Jiaqi Wang, Shee-Mei Lok 4 5 Program in Emerging Infectious Diseases, Duke–NUS Graduate Medical School, KTPExpand
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Capsid protein structure in Zika virus reveals the flavivirus assembly process
Structures of flavivirus (dengue virus and Zika virus) particles are known to near-atomic resolution and show detailed structure and arrangement of their surface proteins (E and prM in immature virusExpand
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