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A Cellular Mechanism for the Generation of Ventricular Arrhythmias by Acetylstrophanthidin
Transmembrane activity was recorded from canine false tendons bathed with Tyrode's solution at 37°C. Stimulus patterns provided a 3-second pause after every ten beats. Acetylstrophanthidin was… Expand
Contractions in guinea-pig ventricular myocytes triggered by a calcium-release mechanism separate from Na+ and L-currents.
1. Unloaded cell shortening and membrane currents were examined in isolated guinea-pig ventricular myocytes at 37 degrees C using video edge detection and single-electrode voltage clamp. 2. Inward… Expand
Role of cAMP-dependent protein kinase A in activation of a voltage-sensitive release mechanism for cardiac contraction in guinea-pig myocytes.
- G. Ferrier, J. Zhu, I. M. Redondo, S. Howlett
- Chemistry, Medicine
- The Journal of physiology
- 1 November 1998
1. Ionic currents and unloaded cell shortening were recorded from guinea-pig ventricular myocytes with single electrode voltage clamp techniques and video edge detection at 37 C. Patch pipettes (1-3… Expand
Calcium spark properties in ventricular myocytes are altered in aged mice.
- S. Howlett, S. Grandy, G. Ferrier
- Biology, Medicine
- American journal of physiology. Heart and…
- 1 April 2006
This study determined whether whole cell Ca(2+) transients and unitary sarcoplasmic reticulum (SR) Ca(2+) release events are constant throughout adult life or whether Ca(2+) release is altered in… Expand
Digitalis arrhythmias: role of oscillatory afterpotentials.
- G. Ferrier
- Progress in cardiovascular diseases
- 1 May 1977
Digitalis-induced OAP provide a mechanism of automaticity that may be responsible for many arrhythmias induced by cardiac glycosides. In response to digitalis, OAP occur in tissues of the specialized… Expand
Possible Mechanisms of Ventricular Arrhythmias Elicited by Ischemia followed by Reperfusion Studies on Isolated Canine Ventricular Tissues
The purpose of this study was to develop an isolated tissue model in which arrhythmic activity could be generated in response to conditions encountered in ischemia followed by reperfusion, and in… Expand
”Voltage-activated Ca release” in rabbit, rat and guinea-pig cardiac myocytes, and modulation by internal cAMP
Abstract It is widely believed that Ca release from the sarcoplasmic reticulum (SR) in heart muscle is due to ”Ca-induced Ca-release” (CICR), triggered by transmembrane Ca entry. However, in intact… Expand
Effect of Calcium on Acetylstrophanthidin‐Induced Transient Depolarizations in Canine Purkinje Tissue
The role of calcium ions (Ca2+) in the generation of transient depolarizations (TDs) by acetylstrophanthidin was examined. Transmembrane activity was recorded from isolated canine false tendons… Expand
Differential effects of docosahexaenoic acid on contractions and L-type Ca2+ current in adult cardiac myocytes.
UNLABELLED Beneficial effects of n-3 polyunsaturated fatty acids in Ca2+ overload have been attributed to blockade of L-type Ca2+ current (I(Ca-L)). However, cardiac contractions may be maintained… Expand
Contribution of a voltage-sensitive calcium release mechanism to contraction in cardiac ventricular myocytes.
The contribution of a voltage-sensitive release mechanism (VSRM) for sarcoplasmic reticulum (SR) Ca2+ to contraction was investigated in voltage-clamped ventricular myocytes at 37 degrees C. Na+… Expand