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Muscle regeneration by bone marrow-derived myogenic progenitors.
TLDR
Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers. Expand
HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia.
TLDR
The data show that genetic manipulation of donor lymphocytes may increase the efficacy and safety of allo-BMT and expand its application to a larger number of patients. Expand
Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells
TLDR
Ex vivo gene therapy of JEB is feasible and leads to full functional correction of the disease, and retroviral integration site analysis indicated that the regenerated epidermis is maintained by a defined repertoire of transduced stem cells. Expand
Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA− Immunodeficient Patients
TLDR
Results indicate successful gene transfer into long-lasting progenitor cells, producing a functional multilineage progeny. Expand
Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets.
TLDR
The chemokine receptor repertoire of human BM-MSCs that determines their migratory activity is defined and modulation of homing capacity may be instrumental for harnessing the therapeutic potential of BM- MSCs. Expand
Muscle-derived hematopoietic stem cells are hematopoietic in origin
TLDR
Fractionated muscle cells are fractionated on the basis of hematopoietic markers to show that the active population exclusively expresses the hematoplastic stem cell antigens Sca-1 and CD45. Expand
Protein Kinase A-Mediated Synapsin I Phosphorylation Is a Central Modulator of Ca2+-Dependent Synaptic Activity
TLDR
Data define a hierarchical crosstalk between cAMP- and CaM-dependent cascades and point to synapsin as a major effector of PKA in the modulation of activity-dependent SV exocytosis, which is primarily caused by calmodulin-dependent activation of cAMP pathways rather than by direct activation of CaM kinases. Expand
Hypomorphic Mutation of the TALE Gene Prep1 (pKnox1) Causes a Major Reduction of Pbx and Meis Proteins and a Pleiotropic Embryonic Phenotype
TLDR
The data indicate that Prep1 is an essential gene that acts upstream of and within a Pbx-Meis network that regulates multiple aspects of embryonic development. Expand
High efficiency myogenic conversion of human fibroblasts by adenoviral vector-mediated MyoD gene transfer. An alternative strategy for ex vivo gene therapy of primary myopathies.
TLDR
The feasibility of an alternative approach to gene therapy of primary myopathies, based on implantation of large numbers of genetically modified primary fibroblasts massively converted to myogenesis by adenoviral delivery of MyoD ex vivo, is supported. Expand
The second transferrin receptor regulates red blood cell production in mice.
TLDR
It is suggested that Tfr2 is a component of a novel iron-sensing mechanism that adjusts erythroid production according to iron availability, likely by modulating the erythroblast Epo sensitivity. Expand
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