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Psychrophilic enzymes: hot topics in cold adaptation
TLDR
The ability to thrive at temperatures that are close to, or below, the freezing point of water requires a vast array of adaptations to maintain the metabolic rates and sustained growth compatible with life in these severe environmental conditions.
Psychrophilic microorganisms: challenges for life
TLDR
The ability of psychrophiles to survive and proliferate at low temperatures implies that they have overcome key barriers inherent to permanently cold environments, and the current knowledge of these adaptations as gained from extensive biochemical and biophysical studies and also from genomics and proteomics is discussed.
Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125.
TLDR
The analysis of the genome sequence of the fast growing Antarctica bacterium Pseudoalteromonas haloplanktis TAC125 finds that it copes with the increased solubility of oxygen at low temperature by multiplying dioxygen scavenging while deleting whole pathways producing reactive oxygen species.
Cold-adapted enzymes: from fundamentals to biotechnology.
Psychrophilic enzymes: molecular basis of cold adaptation
TLDR
All known structural factors and weak interactions involved in protein stability are either reduced in number or modified in order to increase their flexibility, and thermal instability of cold-adapted enzymes is regarded as a consequence of their conformational flexibility.
Psychrophilic Enzymes: From Folding to Function and Biotechnology
TLDR
Psychrophiles thriving permanently at near-zero temperatures synthesize cold-active enzymes to sustain their cell cycle and these enzymes are already used in many biotechnological applications requiring high activity at mild temperatures or fast heat-inactivation rate.
Psychrophilic enzymes: a thermodynamic challenge.
Some like it cold: biocatalysis at low temperatures.
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