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Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells.
It is suggested that BAC induces cell growth arrest and death at a concentration as low as 0.0001%, which could in part explain some ocular surface disorders observed in patients undergoing long-term topical treatments with preservative-containing drugs. Expand
Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagy.
The findings show that starvation-induced autophagy in the human liver may be involved in liver cell death during anorexia nervosa, even though other mechanisms of liver cell damage could also play a role. Expand
Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes.
It is suggested that ATP depletion and lipid peroxidation may cause cell death and that lipid per oxidation products may account, in part, for other steatohepatitis lesions. Expand
Expression of cell-cell and cell-matrix adhesion proteins by sinusoidal endothelial cells in the normal and cirrhotic human liver.
Normal sinusoidal endothelial cells express a distinctive set of cell-adhesion molecules, adapted to their structural and microenvironmental characteristics, and this repertory is dramatically modified during Sinusoidal capillarization, possibly as a consequence of the concomitant matrix changes. Expand
Uncoupling of rat and human mitochondria: a possible explanation for tacrine-induced liver dysfunction.
The weak base tacrine exerts a protonophoric effect in mitochondria that wastes energy and decreases levels of adenosine triphosphate in rat and human cells, which might be involved in tacrine-induced liver dysfunction. Expand
Tamoxifen Inhibits Topoisomerases, Depletes Mitochondrial DNA, and Triggers Steatosis in Mouse Liver
Tamoxifen decreases hepatic triglyceride secretion, and it accumulates electrophoretically in mitochondria, where it impairs β-oxidation and respiration, thus causing hepatic steatosis despite a secondary down-regulation of hepatic fatty acid synthase expression. Expand
MYO5B and bile salt export pump contribute to cholestatic liver disorder in microvillous inclusion disease
The results suggest that cholestasis in MVID patients results from impairment of the MYO5B/RAB11A apical recycling endosome pathway in hepatocytes, altered targeting of BSEP to the canalicular membrane, and increased ileal BA absorption. Expand
Relationship between vascular development and vascular differentiation during liver organogenesis in humans.
The development of the hepatic vascular architecture is a multistep process combining angiogenesis, vasculogenesis and vascular differentiation, regulated by specific growth and differentiation factors including VEGF. Expand
Structural and functional differentiation of sinusoidal endothelial cells during liver organogenesis in humans.
During fetal life, human liver sinusoids, which differentiate between 4 and 12 weeks of gestation from capillaries of the septum transversum, must support an important hematopoietic function andExpand
Effects of female sex hormones on mitochondria: possible role in acute fatty liver of pregnancy.
It is concluded that female sex hormones have deleterious effects on liver mitochondria and suggested that these effects, together with other factors, may contribute to the development of acute fatty liver of pregnancy in some women. Expand