G. Farrugia

Publications567
h-index66
Citations15,305
Highly Influential Citations544
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Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract.
Populations of interstitial cells of Cajal (ICC) are altered in several gastrointestinal neuromuscular disorders. ICC are identified typically by ultrastructure and expression of Kit (CD117), a… Expand
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Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells
Gut microbiota alterations have been described in several diseases with altered gastrointestinal (GI) motility, and awareness is increasing regarding the role of the gut microbiome in modulating GI… Expand
  • 359
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Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies.
BACKGROUND Idiopathic autonomic neuropathy is a severe, subacute disorder with a presumed autoimmune basis. It is indistinguishable from the subacute autonomic neuropathy that may accompany lung… Expand
  • 535
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Syntrophin mutation associated with long QT syndrome through activation of the nNOS–SCN5A macromolecular complex
Mutations in 11 genes that encode ion channels or their associated proteins cause inherited long QT syndrome (LQTS) and account for ≈75–80% of cases (LQT1–11). Direct sequencing of SNTA1, the gene… Expand
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Interstitial cells of Cajal in health and disease
  • G. Farrugia
  • Biology, Medicine
  • Neurogastroenterology and motility : the official…
  • 1 May 2008
Abstract  The gastrointestinal tract serves the physiological function of digesting and absorbing nutrients from food and physically mixing and propelling these contents in an oral to anal direction.… Expand
  • 308
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Treatment of gastroparesis: a multidisciplinary clinical review
Abstract  This clinical review on the treatment of patients with gastroparesis is a consensus document developed by the American Motility Society Task Force on Gastroparesis. It is a… Expand
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Diabetic gastroparesis: what we have learned and had to unlearn in the past 5 years
Diabetic gastroparesis is a disorder that occurs in both type 1 and type 2 diabetes. It is associated with considerable morbidity among these patients and with the resultant economic burden on the… Expand
  • 145
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Heme oxygenase 2 is present in interstitial cell networks of the mouse small intestine.
BACKGROUND & AIMS The interstitial cell (IC) network may be of fundamental importance in regulating gastrointestinal motility. Intestinal smooth muscle cells are depolarized in the absence of ICs,… Expand
  • 84
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Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting
Background  Despite the relatively high prevelance of gastroparesis and functional dyspepsia, the aetiology and pathophysiology of these disorders remain incompletely understood. Similarly, the… Expand
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American Journal of Physiology: Gastrointestinal and Liver Physiology American Journal of Physiology: Heart and Circulatory Physi- QlQgY American Journal of Physiology: Regulatory, Integrative and…
s Invited for Fourth Annual Workshop on PULMONARY PHYSIOLOGY AND FUNCTlON TESTlNG IN SMALL LABORATORY ANI Satellite Conference to the Annual Meeting of the AMERICAN THORACIC SOCIETY
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