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Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract.

TLDR
Ano1 labels all classes of ICC and represents a highly specific marker for studying the distribution of ICC in mouse and human tissues with an advantage over Kit since it does not label mast cells.
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Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells

TLDR
Gut microbiota acting through SCFAs are important determinants of enteric 5‐HT production and homeostasis through an effect of short‐chain fatty acids on enterochromaffin cells.
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Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies.

TLDR
Seropositivity for antibodies that bind to or block ganglionic acetylcholine receptors identifies patients with various forms of autoimmune autonomic neuropathy and distinguishes these disorders from other types of dysautonomia.
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Syntrophin mutation associated with long QT syndrome through activation of the nNOS–SCN5A macromolecular complex

TLDR
It is concluded that the A390V mutation disrupted binding with PMCA4b, released inhibition of nNOS, caused S-nitrosylation of SCN5A, and was associated with increased late sodium current, which is the characteristic biophysical dysfunction for sodium-channel-mediated LQTS (LQT3).
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Interstitial cells of Cajal in health and disease

  • G. Farrugia
  • Medicine, Biology
    Neurogastroenterology and motility : the official…
  • 1 May 2008
TLDR
This review will describe what is known about the function and role of ICC both in health and in a variety of motility disorders with a focus on unresolved issues pertaining to their role in the control of gastrointestinal motility.
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Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: A Systematic Review and Meta-analysis.

TLDR
In a systematic review and meta-analysis, it is found >10% of patients with infectious enteritis develop IBS later; risk of IBS was 4-fold higher than in individuals who did not have infectiousEnteritis, although there was heterogeneity among studies analyzed.
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Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting

TLDR
The aetiology and pathophysiology of gastroparesis and functional dyspepsia remain incompletely understood and the diagnostic and treatment options for these two disorders are relatively limited.
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Diabetic gastroparesis: what we have learned and had to unlearn in the past 5 years

TLDR
The epidemiology, pathogenesis, diagnosis and treatment of diabetic gastroparesis are reviewed, focusing on the areas that are still controversial and those that require more studies.
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Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall.

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Decreased interstitial cell of cajal volume in patients with slow-transit constipation.

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