• Publications
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Chemokine receptor internalization and intracellular trafficking.
This review discusses the current knowledge and controversies regarding the internalization and trafficking of viral and decoy chemokine receptors and their effects on trafficking, chemotaxis and signaling. Expand
Retinoic Acid Attenuates β-Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model
A robust decrease in brain Aβ deposition and tau phosphorylation is reported in the blinded study of APP/PS1 transgenic mice treated intraperitoneally for 8 weeks with ATRA, which support ATRA as an effective therapeutic agent for the prevention and treatment of AD. Expand
Chemokine CXCL12 Induces Binding of Ferritin Heavy Chain to the Chemokine Receptor CXCR4, Alters CXCR4 Signaling, and Induces Phosphorylation and Nuclear Translocation of Ferritin Heavy Chain*
Chemokine receptor-initiated signaling plays critical roles in cell differentiation, proliferation, and migration. However, the regulation of chemokine receptor signaling under physiological andExpand
Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence.
It is reported that inhibition of CaMKII by intrahippocampal dentate gyrus administration of the specific inhibitors KN-62 and KN-93 to rats significantly attenuated the tolerance to the analgesic effect of morphine and the abstinence syndrome precipitated by opiate antagonist naloxone. Expand
Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis.
Data indicate that Rab11-FIP2 and myosin Vb regulate CX CR2 recycling and receptor-mediated chemotaxis and that passage of internalized CXCR2 through Rab11a-positive recycling system is critical for physiological response to a chemokine. Expand
Differential regulation of CXCR2 trafficking by Rab GTPases.
The present study demonstrated that CXCR2 was colocalized with transferrin and low-density lipoprotein (LDL) after agonist treatment for different periods of time, suggesting 2 intracellular trafficking pathways for this receptor. Expand
The chemotaxis of M1 and M2 macrophages is regulated by different chemokines
Screening chemokines that differentially induce chemotaxis of M1 and M2 macrophages and finding CCR7, the receptor for CCL19/CCL21, appeared to be an exception suggest that recruitment of M 1 and M1 macrophaging is fine tuned by different Chemokines with the involvement of specific signaling pathways. Expand
Cyclophilin A Is Required for CXCR4-mediated Nuclear Export of Heterogeneous Nuclear Ribonucleoprotein A2, Activation and Nuclear Translocation of ERK1/2, and Chemotactic Cell Migration*
  • H. Pan, C. Luo, +6 authors G. Fan
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 4 January 2008
It is demonstrated that CXCR4 was co-immunoprecipitated with cyclophilin A (CyPA) from the lysate of HEK293 cells stably expressing CX CR4, and a critical role of the receptor C terminus is suggested in this interaction. Expand
Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation*
The observation that a mutant of CXCR4, HA-3K/R CX CR4, which cannot be ubiquitinated and does not mediate a chemotactic response to CXCL12, indicates the importance of this covalent modification not only in marking receptors for degradation but also for permitting CxCR4-mediated signaling. Expand
Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization.
A role for the LLKIL motif in the carboxyl terminus of CXCR2 in receptor internalization and cell chemotaxis is demonstrated and imply a role for adaptin 2 in the endocytosis of C XCR2. Expand