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Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction.
Rheumatoid arthritis is an autoimmune disease characterized by the production of two known antibodies - rheumatoid factor and anti-citrullinated peptide antibody (ACPA) - against common autoantigensExpand
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Interleukin-23: A key cytokine in inflammatory diseases
Abstract Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, p19 and p40. The p40 subunit is shared with IL-12. IL-23 and IL-12 have different receptors and differentExpand
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Epidemiology of Primary Sjögren's Syndrome in a French Multiracial/Multiethnic Area
To describe the epidemiology of primary Sjögren's syndrome (SS) in a multiracial/multiethnic population.
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Vitamin D and inflammation.
Calcitriol, or 1,25-dihydroxyvitamin D3 (1,25(OH)(2)D3) is a well-known endocrine regulator of calcium homeostasis. More recently, local calcitriol production by immune cells was shown to exertExpand
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Defective costimulatory function is a striking feature of antigen-presenting cells in an HLA-B27-transgenic rat model of spondylarthropathy.
OBJECTIVE A disease resembling the human spondylarthropathies develops in HLA-B27-transgenic rats. This disease in rats is mediated by CD4+ T cells, but antigen-presenting cells (APCs) may also playExpand
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Systemic inflammatory and autoimmune manifestations associated with myelodysplastic syndromes and chronic myelomonocytic leukaemia: a French multicentre retrospective study.
OBJECTIVE We describe myelodysplastic syndrome (MDS)-associated systemic inflammatory and autoimmune diseases (SIADs), their treatments and outcomes and the impact of SIADs on overall survival in aExpand
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In Antisynthetase Syndrome, ACPA Are Associated With Severe and Erosive Arthritis
AbstractAnticitrullinated peptide/protein antibodies (ACPA), which are highly specific for rheumatoid arthritis (RA), may be found in some patients with other systemic autoimmune diseases. TheExpand
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DNA microarray allows molecular profiling of rheumatoid arthritis and identification of pathophysiological targets
This study was undertaken to evaluate the possibility to obtain a molecular signature of rheumatoid arthritis (RA) comparatively osteoarthritis (OA), and to lay the bases to develop new diagnosticExpand
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Rheumatologic manifestations of chronic hepatitis C infection.
The many rheumatologic manifestations associated with chronic hepatitis C virus (HCV) infection include arthralgia, myalgia, arthritis, vasculitis, and sicca syndrome. Arthralgia is the most commonExpand
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Regulatory T cells (Treg) in rheumatoid arthritis.
Modulation of the T-cell response depends chiefly on regulatory T cells (Treg), which express CD4 and CD25. Some Treg cells are present naturally, whereas others are induced in response to antigens.Expand
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