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Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation
Vps4 both recycles ESCRT-III subunits and cooperates with ESCRT-III to drive distinct membrane remodeling steps that lead to efficient membrane scission during the biogenesis of multivesicular bodies.
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Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3
The motor protein Myo5B and t-SNARE Stx3 drive cargo-selective apical exocytosis in polarized epithelial cells in a pathway dependent on v-SNARE–like Slp4a, v-SNARE Vamp7, Sec1/Munc18-like proteinExpand
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An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking
Significance Microvillus inclusion disease (MVID) is a rare intestinal enteropathy resulting in severe diarrhoea in neonates. Here, we have generated an intestine-specific knockout mouse model forExpand
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Loss of syntaxin 3 causes variant microvillus inclusion disease.
Microvillus inclusion disease (MVID) is a disorder of intestinal epithelial differentiation characterized by life-threatening intractable diarrhea. MVID can be diagnosed based on loss of microvilli,Expand
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Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity.
Microvillus inclusion disease (MVID) is a congenital enteropathy characterized by loss of apical microvilli and formation of cytoplasmic inclusions lined by microvilli in enterocytes. MVID is causedExpand
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Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding
The ESCRT machinery mediates reverse membrane scission. By quantitative fluorescence lattice light-sheet microscopy, we have shown that ESCRT-III subunits polymerize rapidly on yeast endosomes,Expand
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Development of an Innovative 3D Cell Culture System to Study Tumour - Stroma Interactions in Non-Small Cell Lung Cancer Cells
Introduction We describe a novel 3D co-culture model using non-small cell lung cancer (NSCLC) cell lines in combination with lung fibroblasts. This model allows the investigation of tumour-stromaExpand
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Disrupted apical exocytosis of cargo vesicles causes enteropathy in FHL5 patients with Munc18-2 mutations.
Familial hemophagocytic lymphohistiocytosis 5 (FHL5) is an autosomal recessive disease caused by mutations in STXBP2, coding for Munc18-2, which is required for SNARE-mediated membrane fusion. FHL5Expand
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LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning
Signaling from lysosomes controls cellular clearance and energy metabolism. Lysosomal malfunction has been implicated in several pathologies, including neurodegeneration, cancer, infection,Expand
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Abnormal Rab11‐Rab8‐vesicles cluster in enterocytes of patients with microvillus inclusion disease
Microvillus inclusion disease (MVID) is a congenital enteropathy characterized by accumulation of vesiculo-tubular endomembranes in the subapical cytoplasm of enterocytes, historically termedExpand
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