G. F. Deleavey
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Designing chemically modified oligonucleotides for targeted gene silencing.
Oligonucleotides (ONs), and their chemically modified mimics, are now routinely used in the laboratory as a means to control the expression of fundamentally interesting or therapeutically relevant… Expand
Chemically modified siRNA: tools and applications.
Chemical modification provides solutions to many of the challenges facing siRNA therapeutics. This review examines the various siRNA modifications available, including every aspect of the RNA… Expand
Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat.
- Keith T. Gagnon, H. M. Pendergraff, +10 authors D. Corey
- Medicine, Biology
- 8 November 2010
Huntington's disease (HD) is a currently incurable neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat within the huntingtin (HTT) gene. Therapeutic approaches include… Expand
Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing
- G. F. Deleavey, J. K. Watts, +7 authors M. Damha
- Biology, Medicine
- Nucleic acids research
- 22 April 2010
We report that combining a DNA analog (2′F-ANA) with rigid RNA analogs [2′F-RNA and/or locked nucleic acid (LNA)] in siRNA duplexes can produce gene silencing agents with enhanced potency. The… Expand
Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids
- Naira Souleimanian, G. F. Deleavey, +4 authors C. Stein
- Biology, Medicine
- Molecular therapy. Nucleic acids
- 1 October 2012
Gymnosis is the process of the delivery of antisense oligodeoxynucleotides to cells, in the absence of any carriers or conjugation, that produces sequence-specific gene silencing. While gymnosis was… Expand
Delivery of Nucleic Acids through the Controlled Disassembly of Multifunctional Nanocomplexes
In this study, novel pH-responsive polyion complex micelles (PICMs) were developed for the efficient delivery of nucleic acid drugs, such as antisense oligonucleotide (AON) and short interfering RNA… Expand
Dramatic effect of furanose C2' substitution on structure and stability: directing the folding of the human telomeric quadruplex with a single fluorine atom.
- Nerea Martín-Pintado, Maryam Yahyaee-Anzahaee, +4 authors C. González
- Medicine, Chemistry
- Journal of the American Chemical Society
- 27 March 2013
Human telomeric DNA quadruplexes can adopt different conformations in solution. We have found that arabinose, 2'F-arabinose, and ribose substitutions stabilize the propeller parallel G-quadruplex… Expand
siRNA nanocarriers based on methacrylic acid copolymers.
- Arnaud E Felber, Bastien Castagner, Mahmoud Elsabahy, G. F. Deleavey, M. Damha, J. Leroux
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 30 May 2011
Poly(ethylene glycol)-b-poly(propyl methacrylate-co-methacrylic acid) (PEG-b-P(PrMA-co-MAA) can be complexed with poly(amido amine) (PAMAM) dendrimers and nucleic acids to form pH-responsive… Expand
Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery.
- Dianna P Y Chan, G. F. Deleavey, S. Owen, M. Damha, M. S. Shoichet
- Materials Science, Medicine
- 1 November 2013
Efficient and targeted cellular delivery of small interfering RNAs (siRNAs) and antisense oligonucleotides (AONs) is a major challenge facing oligonucleotide-based therapeutics. The majority of… Expand
The interactions of amphiphilic antisense oligonucleotides with serum proteins and their effects on in vitro silencing activity.
- Arnaud E Felber, N. Bayó-Puxan, G. F. Deleavey, Bastien Castagner, M. Damha, J. Leroux
- Biology, Medicine
- 1 September 2012
Antisense oligonucleotides (AONs) are a class of compounds with high therapeutic potential. One of the challenges facing this platform is the development of effective techniques to achieve cellular… Expand