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Interferon-&ggr;–Mediated Downregulation of Cholesterol Efflux and ABC1 Expression Is by the Stat1 Pathway
TLDR
The pathway by which IFN-&ggr; inhibited ABC1 expression was investigated with signal transducers and activators of transcription (Stat1) knockout mice showed that Stat1 signaling is necessary and sufficient for the inhibitory effects of IFN; on cholesterol efflux andABC1 expression. Expand
The human Burkitt lymphoma cell line Namalwa represents a homogenous cell system characterized by high levels of Toll-like receptor 9 and activation by CpG oligonucleotides.
TLDR
The results suggest that the Namalwa Burkitt lymphoma line may serve as a useful cell-based assay for the detection of novel TLR9 agonists as well as a model to further explore the regulation ofTLR9 expression and signaling. Expand
Endotoxin tolerance: in vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level.
TLDR
The hyporesponsive state associated with endotoxin tolerance is characterized by transcriptional regulation of both TNF and IL-1 synthesis, which is consistent with a decrease in transcriptional activity by nuclear run-on assays for both cytokines and a reduced amount of the nuclear-associated transcription factor NF-KB. Expand
Differential expression of interleukin-1 and tumor necrosis factor in murine septic shock models.
TLDR
Experiments with adrenalectomized mice suggest that the absence of serum TNF in the CLP model is in part due to the modulatory effects of endogenous corticosteroids, which are effective at preventing death in the endotoxin model and yet had no beneficial effect in antibiotic-treated CLP animals. Expand
Histone deacetylase inhibition results in decreased macrophage CD9 expression.
TLDR
The results demonstrate that HDAC inhibition may modulate macrophage function in part through changes in the expression of membrane proteins associated with matrix interactions. Expand
Transcriptional and post-transcriptional mechanisms involved in the differential expression of LPS-induced IL-1 and TNF mRNA.
TLDR
The cycloheximide-mediated increase in TNF mRNA was also related to an increased stability of the TNF message, while no significant increase in stability was apparent in IL-1 beta mRNA. Expand
Post-transcriptional regulation of macrophage ABCA1, an early response gene to IFN-γ
TLDR
ABCA1 can be considered as an early response gene to macrophage activation by IFN-{gamma} with down-regulation occurring by message destabilization with the kinetics of ABCA1 message and protein decrease consistent with the early IFN -gamma-induced changes in Stat1 phosphorylation and nuclear translocation observed in these cells. Expand
Estriol: A potent regulator of TNF and IL-6 expression in a murine model of endotoxemia
TLDR
The results suggest that the estrogen agonist estriol can have significant quantitative, TNF, and kinetic, IL-6, effects on inflammatory monokines produced in response to an endotoxin challenge. Expand
In Vivo Dexamethasone Effects on Neutrophil Effector Functions in a Rat Model of Acute Lung Injury
TLDR
The neutrophil population which has migrated into the airways in dexamethasone pretreated rats retains the capacity to mediate host defense but also to exacerbate inflammation associated tissue damage. Expand
Down-regulation of macrophage CD9 expression by interferon-gamma.
TLDR
The expression of CD9 on primary cultures of murine peritoneal macrophages was down regulated by Interferon-Gamma, IFN-gamma, and changes in surface expression were consistent with similar reductions in CD9 protein and message levels by Western and Northern blot analyses. Expand
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