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- Publications
- Influence
90-day feeding and one-generation reproduction study in Crl:CD BR rats with 17 beta-estradiol.
- L. B. Biegel, J. Flaws, +8 authors S. Frame
- Biology, Medicine
- Toxicological sciences : an official journal of…
- 1 August 1998
Over the past several years, there has been increasing concern that chemicals and pesticides found in the environment may mimic endogenous estrogens, potentially producing adverse effects in wildlife… Expand
Possible incorporation of an immunotoxicological functional assay for assessing humoral immunity for hazard identification purposes in rats on standard toxicology study.
- G. Ladics, C. Smith, K. Heaps, G. Elliott, T. W. Slone, S. Loveless
- Biology, Medicine
- Toxicology
- 27 February 1995
The objective of this study was to examine the feasibility of conducting an immunotoxicological assay for assessing humoral immunity in rats on standard toxicology study. Male CD rats were untreated… Expand
Chronic toxicity/oncogenicity of dimethylformamide in rats and mice following inhalation exposure.
- L. Malley, T. W. Slone, +4 authors G. Kennedy
- Medicine
- Fundamental and applied toxicology : official…
- 1994
The potential chronic toxicity and oncogenicity of dimethyl-formamide (DMF) was evaluated by exposing male and female rats and mice to 0, 25, 100, or 400 ppm DMF for 6 hr/day, 5 days/week for 18… Expand
Mechanisms for the pancreatic oncogenic effects of the peroxisome proliferator Wyeth-14,643.
- J. D. Obourn, S. Frame, R. Bell, D. Longnecker, G. Elliott, J. Cook
- Biology, Medicine
- Toxicology and applied pharmacology
- 1 August 1997
Several peroxisome proliferators have been shown to produce pancreatic acinar cell hyperplasia/adenocarcinomas in 2-year bioassays with rats: ammonium perfluorooctanoate (C8), clofibrate,… Expand
90-Day Feeding and One-Generation Reproduction Study in Crl : CD BR Rats with 17 / 3-Estradiol 1
- L. B. Biegel, J. Flaws, +7 authors J. Cook
- 2005
Over the past several years, there has been increasing concern that chemicals and pesticides found in the environment may mimic endogenous estrogens, potentially producing adverse effects in wildlife… Expand
Further evaluation of the incorporation of an immunotoxicological functional assay for assessing humoral immunity for hazard identification purposes in rats in a standard toxicology study.
- G. Ladics, C. Smith, G. Elliott, T. W. Slone, S. Loveless
- Biology, Medicine
- Toxicology
- 13 March 1998
A previous study (Ladics et al., 1995) conducted in our laboratory using the known immunosuppressant agent, cyclophosphamide, indicated that a functional assay for assessment of humoral immunity may… Expand
Subchronic toxicity of 4-vinylcyclohexene in rats and mice by inhalation exposure.
- C. Bevan, J. Stadler, +5 authors A. Panepinto
- Biology, Medicine
- Fundamental and applied toxicology : official…
- 1 July 1996
This study was conducted to evaluate the subchronic toxicity of 4-vinylcyclohexene (VCH). Male and female Sprague-Dawley rats and B6C3F1 mice were exposed by inhalation to VCH 6 hr/day, 5 days/week… Expand
CHRONIC TOXICITY AND ONCOGENICITY OF N-METHYLPYRROLIDONE (NMP) IN RATS AND MICE BY DIETARY ADMINISTRATION
- L. Malley, G. Kennedy, +8 authors J. Griffiths
- Medicine
- Drug and chemical toxicology
- 1 January 2001
A two-year feeding study in rats and an 18-month feeding study in mice were conducted to evaluate the potential chronic toxicity and oncogenicity of NMP in Crl : CD® (SD)BR rats and B6C3F1/CrlBR… Expand
Preclinical Safety and Pharmacokinetics of Recombinant Human Factor XIII
Factor XIII (FXIII) is a thrombin-activated protransglutaminase responsible for fibrin clot stabilization and longevity. Deficiency in FXIII is associated with diffuse bleeding and wound-healing… Expand
Cellular immune responses in pigs fed a vitamin E- and selenium-deficient diet.
- M. Lessard, W. C. Yang, +5 authors R. Schultz
- Biology, Medicine
- Journal of animal science
- 1 April 1991
The effects of dietary restriction of vitamin E (Vit E) and selenium (Se) on lymphocyte proliferation, natural killer (NK) cell activity, antibody-dependent cell-mediated cytotoxicity (ADCC), and on… Expand
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