• Publications
  • Influence
Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.
TLDR
Acycloguanosine triphosphate inhibits herpes simplex virus DNA polymerase (DNA nucleotidyltransferase) 10-30 times more effectively than cellular (HeLa S3) DNA polymerases, contributing to the drug's selectivity.
The purine path to chemotherapy
  • G. Elion
  • Medicine
    In Vitro Cellular & Developmental Biology
  • 1 April 1989
TLDR
Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia, gout and hyperuricemia, and herpesvirus infections, and for the prevention of organ transplant rejection.
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
TLDR
Low acyclo-Guo phosphorylating levels in cells infected with either of two herpes simplex virus mutants or with vaccinia virus correlated with low effectiveness of the compound against the virus in tissue culture.
9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group
Of a series of nucleoside analogues synthesized, 9-(2-hydroxy-ethoxymethyl)guanine was found to have marked antiviral activity in animal models of herpes virus infections, associated with very low
Mechanism of action and selectivity of acyclovir.
  • G. Elion
  • Biology, Chemistry
    The American journal of medicine
  • 20 July 1982
Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies.
TLDR
Nelarabine is a novel nucleoside with significant cytotoxic activity against malignant T cells and Dose-limiting toxicity (DLT) was neurologic in both children and adults.
Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity.
...
...