• Publications
  • Influence
On the mechanism of inactivation of xanthine oxidase by allopurinol and other pyrazolo[3,4-d]pyrimidines.
Abstract Allopurinol and other 6-unsubstituted pyrazolo[3,4-d]-pyrimidines have been shown to reduce all of the oxidation-reduction reactive groups of milk xanthine oxidase. The great inhibitoryExpand
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The purine path to chemotherapy
  • G. Elion
  • Biology, Medicine
  • In Vitro Cellular & Developmental Biology
  • 1 April 1989
Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirusExpand
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A comparison of the specificities of xanthine oxidase and aldehyde oxidase.
Abstract This study directly compares the specificities of the structurally similar hydroxylating enzymes, aldehyde oxidase and xanthine oxidase. Michaelis-Menten constants for a variety ofExpand
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Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
9-(2-Hydroxyethoxymethyl)guanine (acyclo-Guo), is an effective and selective inhibitor of herpes simplex virus replication. This purine nucleoside analogue was found to be phosphorylated at a 30toExpand
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Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies.
PURPOSE A phase I study was conducted to determine the maximum-tolerated dose (MTD), toxicity profile, and pharmacokinetics of a novel purine nucleoside, nelarabine, a soluble prodrug ofExpand
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The disposition of acyclovir in different species.
The absorption, distribution and biotransformation of the antiviral drug acyclovir were investigated in several species. Its oral administration resulted in better absorption and higher plasma levelsExpand
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Metabolic studies of allopurinol, an inhibitor of xanthine oxidase.
Abstract The metabolic disposition of allopurinol [4-hydroxypyrazolo(3,4-d)-pyrimidine) was determined in mice, dogs, and human subjects. The drug is a substrate for, as well as an inhibitor of,Expand
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The purine path to chemotherapy
Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirusExpand
  • 296
  • 4
Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity.
Kinetic constants were determined for 34 nucleoside substrates of deoxycytidine kinase (EC 2.7.1.74) from calf thymus. Substrate efficiency was assessed by the ratio of Vmax to Km. InhibitionExpand
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