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Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.
- G. Elion, P. Furman, J. A. Fyfe, P. de Miranda, L. Beauchamp, H. Schaeffer
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 December 1977
Acycloguanosine triphosphate inhibits herpes simplex virus DNA polymerase (DNA nucleotidyltransferase) 10-30 times more effectively than cellular (HeLa S3) DNA polymerases, contributing to the drug's selectivity.
On the mechanism of inactivation of xanthine oxidase by allopurinol and other pyrazolo[3,4-d]pyrimidines.
The purine path to chemotherapy
- G. Elion
- MedicineIn Vitro Cellular & Developmental Biology
- 1 April 1989
Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia, gout and hyperuricemia, and herpesvirus infections, and for the prevention of organ transplant rejection.
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
- J. A. Fyfe, P. Keller, P. Furman, R. Miller, G. Elion
- Biology, ChemistryThe Journal of biological chemistry
- 25 December 1978
Low acyclo-Guo phosphorylating levels in cells infected with either of two herpes simplex virus mutants or with vaccinia virus correlated with low effectiveness of the compound against the virus in tissue culture.
9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group
- H. Schaeffer, L. Beauchamp, P. Miranda, G. Elion, D. J. Bauer, P. Collins
- Chemistry, BiologyNature
- 13 April 1978
Of a series of nucleoside analogues synthesized, 9-(2-hydroxy-ethoxymethyl)guanine was found to have marked antiviral activity in animal models of herpes virus infections, associated with very low…
A comparison of the specificities of xanthine oxidase and aldehyde oxidase.
Mechanism of action and selectivity of acyclovir.
- G. Elion
- Biology, ChemistryThe American journal of medicine
- 20 July 1982
Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies.
- J. Kurtzberg, T. Ernst, B. Mitchell
- MedicineJournal of clinical oncology : official journal…
- 20 May 2005
Nelarabine is a novel nucleoside with significant cytotoxic activity against malignant T cells and Dose-limiting toxicity (DLT) was neurologic in both children and adults.
Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues.
- G. Elion
- BiologyFederation proceedings