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Modelling and analysis of local field potentials for studying the function of cortical circuits
TLDR
Careful mathematical modelling and analysis are needed to take full advantage of the opportunities that this signal offers in understanding signal processing in cortical circuits and, ultimately, the neural basis of perception and cognition. Expand
From grid cells to place cells: A mathematical model
TLDR
A model in which place fields of hippocampal pyramidal cells are formed by linear summation of appropriately weighted inputs from entorhinal grid cells is proposed, which points to a number of possible constraints in the organization of functional connections between grid cells and place cells. Expand
Current-source density estimation based on inversion of electrostatic forward solution: Effects of finite extent of neuronal activity and conductivity discontinuities
TLDR
iCSD estimates of stimulus-evoked responses measured with laminar electrodes in the rat somatosensory (barrel) cortex are compared to estimates from the standard CSD method. Expand
Modeling the Spatial Reach of the LFP
TLDR
The size of the generating region depends on the neuron morphology, the synapse distribution, and the correlation in synaptic activity, and is investigated by simulating the LFP from a large number of neurons around the electrode. Expand
Intrinsic dendritic filtering gives low-pass power spectra of local field potentials
TLDR
Two approximate schemes for calculating the LFP, the dipole approximation and the two-monopole approximation, are tested and found to be potentially useful for translating results from large-scale neural network models into predictions for results from electroencephalographic or electrocorticographic recordings. Expand
Amplitude variability and extracellular low-pass filtering of neuronal spikes.
TLDR
The influence of neural morphology and passive electrical parameters on the width and amplitude of extracellular spikes is investigated by combined analytical and numerical investigations of idealized and anatomically reconstructed pyramidal and stellate neuron models and a spike-width increase with increasing distance from soma is seen. Expand
In vivo Stimulus-Induced Vasodilation Occurs without IP3 Receptor Activation and May Precede Astrocytic Calcium Increase
TLDR
The results in wild-type (WT) mice indicate that in vivo onset of astrocytic calcium increase in response to sensory stimulus could be considerably delayed relative to the simultaneously measured onset of arteriolar dilation, suggesting astroCytes may not play a role in the initiation of blood flow response, at least not via calcium-dependent mechanisms. Expand
Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation
TLDR
Best practices on how field potential recordings (EEG, MEG, ECoG and LFP) can be analyzed to identify large-scale brain dynamics, and highlights issues and limitations of interpretation are presented. Expand
Towards reliable spike-train recordings from thousands of neurons with multielectrodes
TLDR
Some of the challenges that must be met to achieve the critical need of realistic model data to be used as ground truth in the validation of spike-sorting algorithms are described. Expand
Computing the Local Field Potential (LFP) from Integrate-and-Fire Network Models
TLDR
The results provide a simple formula for estimating the time course of the LFP from LIF network simulations in cases where a single pyramidal population dominates the L FP generation, and thereby facilitate quantitative comparison between computational models and experimental LFP recordings in vivo. Expand
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