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Genome-wide atlas of gene expression in the adult mouse brain
An anatomically comprehensive digital atlas containing the expression patterns of ∼20,000 genes in the adult mouse brain is described, providing an open, primary data resource for a wide variety of further studies concerning brain organization and function. Expand
Mutation of the Angelman Ubiquitin Ligase in Mice Causes Increased Cytoplasmic p53 and Deficits of Contextual Learning and Long-Term Potentiation
The cytoplasmic abundance of p53 was increased in postmitotic neurons in m-/p+ mice and in AS, providing a potential biochemical basis for the phenotype through failure to ubiquitinate and degrade various effectors. Expand
A Differential Response of Two Putative Mammalian Circadian Regulators, mper1 and mper2, to Light
It appears that mper1 is the pacemaker component which responds to light and thus mediates photic entrainment in Drosophila period and mper2. Expand
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
Developmental arrest in Brca2-deficient embryos, their radiation sensitivity, and the association of Brca1 with Rad51 indicate that Brca 2 may be an essential cofactor in the Rad51-dependent DNA repair of double-strand breaks, thereby explaining the tumour-suppressor function of BrCA2. Expand
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
An experimental approach is reported that has identified 9-cis RA as an RXR ligand, up to 40-fold more potent than all-trans RA in transfection assays and binds with high affinity. Expand
Nonredundant Roles of the mPer1 and mPer2 Genes in the Mammalian Circadian Clock
The studies show that mPER1 and mPER2 have distinct and complementary roles in the mouse clock mechanism, suggesting independent controls by the two proteins over some output pathways. Expand
RIGUI, a Putative Mammalian Ortholog of the Drosophila period Gene
The molecular components of mammalian circadian clocks are elusive. We have isolated a human gene termed RIGUI that encodes a bHLH/PAS protein 44% homologous to Drosophila period. The highlyExpand
The mPer2 gene encodes a functional component of the mammalian circadian clock
Evidence that an mPer gene functions in the circadian clock is provided, and mPer2 is defined as a component of the mammalian circadian oscillator. Expand
GenePaint.org: an atlas of gene expression patterns in the mouse embryo
The resulting images of gene expression patterns, chiefly of E14.5 mouse embryos, are accessible to the public at http://www.genepaint.org, a relational database that is searchable for gene identifiers and RNA probe sequences. Expand
The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock.
In mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks found throughout the body coordinate circadian rhythms of behavior and physiology. We characterize the clock ofExpand