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Genetic studies of body mass index yield new insights for obesity biology
TLDR
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility. Expand
Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits
TLDR
It is reported that common genetic variants in the FTO gene are associated with substantial changes in BMI, hip circumference, and body weight, which could have a significant impact on the risk of obesity-related morbidity in the general population. Expand
Discovery and Refinement of Loci Associated with Lipid Levels
TLDR
It is found that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Expand
Genome-wide association study of blood pressure and hypertension
TLDR
A genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium identifies 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10−7. Expand
Defining the role of common variation in the genomic and biological architecture of adult human height
TLDR
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid. Expand
New genetic loci link adipose and insulin biology to body fat distribution
TLDR
A genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. Expand
Multiple loci associated with indices of renal function and chronic kidney disease
TLDR
These findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease. Expand
Common variants associated with plasma triglycerides and risk for coronary artery disease
TLDR
It is suggested that triglyceride-rich lipoproteins causally influence risk for CAD, and the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. Expand
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
TLDR
A genome-wide association study is carried out in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations, providing new insight into genetic mechanisms and pathways influencing markers of liver function. Expand
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
TLDR
This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in ery throatcyte measures, and identifies 23 loci significantly associated with these traits. Expand
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