• Publications
  • Influence
New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
TLDR
Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability.
TLDR
The outcome of multiple sclerosis, assessed according to the Kurtzke Disability Status Scale, was reviewed in 1,099 consecutive patients followed in London, Canada, between 1972 and 1984 and the rate at which disability develops after the onset of a progressive phase of MS is presented.
A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.
TLDR
ChIP-seq determination of transcription factor binding, in combination with GWA data, provides a powerful approach to further understanding the molecular bases of complex diseases.
Sex ratio of multiple sclerosis in Canada: a longitudinal study
Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria.
TLDR
Eight patients with a homogeneous syndrome of progressive symmetric spinobulbar spasticity were studied and diagnostic criteria for primary lateral sclerosis based on clinical, laboratory and imaging features are proposed.
Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D
TLDR
This study implicates vitamin D as a strong environmental candidate in MS by demonstrating direct functional interaction with the major locus determining genetic susceptibility by supporting a connection between the main epidemiological and genetic features of this disease.
Environmental factors and multiple sclerosis
  • G. Ebers
  • Biology
    The Lancet Neurology
  • 1 March 2008
The natural history of multiple sclerosis: a geographically based study. 7. Progressive-relapsing and relapsing-progressive multiple sclerosis: a re-evaluation.
TLDR
The validity of the terms 'RP' and 'PR' multiple sclerosis is evaluated in the context of long-term outcome within a large population-based cohort of progressive multiple sclerosis patients seen at the London Multiple Sclerosis Clinic between 1972 and 1984 and provides justification for retaining only PP and SP multiple sclerosis as the subgroups of progressive disease.
Timing of birth and risk of multiple sclerosis: population based study
TLDR
Month of birth and risk of MS are associated, more so in familial cases, implying interactions between genes and environment that are related to climate, particularly during gestation or shortly after birth in individuals born in the northern countries studied.
The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability
TLDR
Relationships between relapses and disability progression for outcomes of requiring assistance to walk, being bedridden and dying from multiple sclerosis by analysing 28 000 patient-years of evolution in 806-bout onset patients from the London Ontario natural history cohort is investigated.
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