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Indomethacin-induced intestinal lesions in the rat.
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Biological effects of inhaled 238PuO2 in beagles.
TLDR
Estimates of cumulative tissue dose in a human exposed to airborne 238PuO2 for 50 years at a rate of one annual limit on intake each year were derived based on a comparison of the data on metabolism for humans and beagles.
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TESTICULAR ATROPHY IN A MULE DEER POPULATION
TLDR
Monitoring mule deer on a former plutonium production site along the Columbia River at the Hanford Site, Washington (USA) revealed 27 (23%) of 116 adult males had unusually shaped, velvet-covered antlers and abnormally developed testicles, indicating permanent sterility.
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Morphology of Spontaneous Brain Tumors in the Rat
TLDR
In lifespan studies of 2,242 rats of three strains, 32 neoplasms were identified in brain, meninges and pineal gland: astrocytoma, ependymoma, meningioma, pinealoma, reticulosis, oligodendroglioma, and gliomatosis.
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Influence of Radon Daughter Exposure Rate, Unattachment Fraction, and Disequilibrium on Occurrence of Lung Tumours
Groups of male, specific-pathogen-free (SPF), Wistar rats were exposed to several concentrations of radon daughters and uranium ore dust to clarify the roles of exposure rate, unattached RaA…
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Microdistribution and long-term retention of 239Pu (NO3)4 in the respiratory tracts of an acutely exposed plutonium worker and experimental beagle dogs.
TLDR
These studies showed that both the human and dogs had a nonuniform distribution of plutonium throughout the lung tissue, and the appearance of retained plutonium within the respiratory tract was inconsistent with current biokinetic models for soluble forms of plutonium.
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Statistical modeling of carcinogenic risks in dogs that inhaled 238PuO2.
TLDR
Combined analyses of data on 260 life-span beagle dogs that inhaled 238PuO2 at the Inhalation Toxicology Research Institute and at Pacific Northwest National Laboratory provided a basis for common risk estimates based on both data sets.
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The distribution and effects of inhaled 239Pu(NO3)4 deposited in the liver of dogs.
TLDR
Liver tumors, principally of bile-duct epithelium, were late-occurring and were observed at lower exposure levels at which life span was not shortened by lung or bone tumors, and there was no effect of exposure level on liver-to-skeleton ratios.
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Hepatic effects of inhaled plutonium dioxide in beagles.
TLDR
Liver tumors were late-occurring neoplasms observed at lower exposure levels where life span was not shortened by lung and bone tumors and Linear regression analysis revealed strong to moderate correlation between cumulative dose and dose rate and time to observed increases in liver enzyme activities.
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Carcinogenic effects of radon daughters, uranium ore dust and cigarette smoke in beagle dogs.
TLDR
The beagle dog is a useful animal for modeling pulmonary lesions produced by uranium mine air contaminants, and exposure to cigarette smoke was found to have a mitigating effect on radon daughter-induced tumors.
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