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A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac
With the availability of complete genome sequence for Drosophila melanogaster, one of the next strategic goals for fly researchers is a complete gene knockout collection. The P-element transposon,Expand
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Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome
In fruit fly research, chromosomal deletions are indispensable tools for mapping mutations, characterizing alleles and identifying interacting loci. Most widely used deletions were generated byExpand
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Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice
OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of body weight. We identified an alternatively spliced transcript that encodes a form of mouse OB-RExpand
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The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
The antimicrobial defence of Drosophila relies largely on the challenge-induced synthesis of an array of potent antimicrobial peptides by the fat body. The defence against Gram-positive bacteria andExpand
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Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis.
We report the molecular characterization of the immune deficiency (imd) gene, which controls antibacterial defense in Drosophila. imd encodes a protein with a death domain similar to that ofExpand
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Identification and mutation analysis of the complete gene for Chediak–Higashi syndrome
Chediak-Higashi syndrome (CHS) is a rare, autosomal recessive disorder characterized by hypopigmentation, severe immunologic deficiency with neutropenia and lack of natural killer (NK) cells, aExpand
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Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53
The importance of p53 in carcinogenesis stems from its central role in inducing cell cycle arrest or apoptosis in response to cellular stresses. We have identified a Drosophila homolog of p53Expand
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The Knockout Mouse Project
Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling forExpand
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A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC).
In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identify genes for inherited disorders. Through theExpand
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Identification of the murine beige gene by YAC complementation and positional cloning
The beige mutation is a murine autosomal recessive disorder, resulting in hypopigmentation, bleeding and immune cell dysfunction. The gene defective in beige is thought to be a homologue of the geneExpand
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