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Alternative splicing: a pivotal step between eukaryotic transcription and translation
Alternative splicing: a pivotal step between eukaryotic transcription and translation Alberto R. Kornblihtt, Ignacio E. Schor, Mariano Alló, Gwendal Dujardin, Ezequiel Petrillo and Manuel J. MuñozExpand
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Alternative splicing: a pivotal step between eukaryotic transcription and translation
Alternative splicing was discovered simultaneously with splicing over three decades ago. Since then, an enormous body of evidence has demonstrated the prevalence of alternative splicing inExpand
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Cotranscriptional exon skipping in the genotoxic stress response
Pre-mRNA splicing is functionally coupled to transcription, and genotoxic stresses can enhance alternative exon inclusion by affecting elongating RNA polymerase II. We report here that variousExpand
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How slow RNA polymerase II elongation favors alternative exon skipping.
Splicing is functionally coupled to transcription, linking the rate of RNA polymerase II (Pol II) elongation and the ability of splicing factors to recognize splice sites (ss) of various strengths.Expand
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Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells
Significance Argonaute proteins are well characterized factors in posttranscriptional gene silencing, the process by which small RNAs trigger mRNA degradation or inhibit translation in the cytoplasm.Expand
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The pathogenicity of splicing defects: mechanistic insights into pre‐mRNA processing inform novel therapeutic approaches
Removal of introns from pre‐mRNA precursors (pre‐mRNA splicing) is a necessary step for the expression of most genes in multicellular organisms, and alternative patterns of intron removal diversifyExpand
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CELF proteins regulate CFTR pre-mRNA splicing: essential role of the divergent domain of ETR-3
Cystic fibrosis is a prominent genetic disease caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Among the many disease-causing alterations are pre-mRNAExpand
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Hu Antigen R (HuR) Is a Positive Regulator of the RNA-binding Proteins TDP-43 and FUS/TLS
  • L. Lu, Lei Zheng, +7 authors P. King
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 19 September 2014
Background: RNA processing abnormalities have been linked to amyotrophic lateral sclerosis (ALS). Results: HuR promotes the expression of the ALS-associated TDP-43 and FUS/TLS RNA-binding proteins.Expand
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Transcriptional elongation and alternative splicing.
Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing isExpand
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Analysis and Implementation of an Electronic Laboratory Notebook in a Biomedical Research Institute
Electronic laboratory notebooks (ELNs) will probably replace paper laboratory notebooks (PLNs) in academic research due to their advantages in data recording, sharing and security. Despite severalExpand
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