• Publications
  • Influence
Update of the Dutch protein evaluation system for ruminants: the DVE/OEB2010 system
SUMMARY In the current Dutch protein evaluation system (the DVE/OEB1991 system), two characteristics are calculated for each feed: true protein digested in the intestine (DVE) and the rumenExpand
Critical Role for TNF in the Induction of Human Antigen-Specific Regulatory T Cells by Tolerogenic Dendritic Cells
TNF is a pleiotropic cytokine with differential effects on immune cells and diseases. Anti-TNF therapy was shown to be effective in rheumatoid arthritis but proved inefficient or even detrimental inExpand
Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers
OBJECTIVE Type 1 diabetes results from selective T-cell–mediated destruction of the insulin-producing β-cells in the pancreas. In this process, islet epitope–specific CD8+ T-cells play a pivotalExpand
Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes
Posttranslational modification (PTM) of islet autoantigens can cause lack of central tolerance in type 1 diabetes (T1D). Tissue transglutaminase (tTG), involved in PTM of gluten antigens in celiacExpand
Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients.
Allogeneic islet transplantation can restore an insulin-independent state in C-peptide-negative type 1 diabetic patients. We recently reported three cases of surviving islet allografts that wereExpand
Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation
Background Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of recipients remains insulin–independent in the following years. We tested the hypothesis that allograftExpand
Economic potential of individual variation in milk yield response to concentrate intake of dairy cows
SUMMARY The objectives of the current study were to quantify the individual variation in daily milk yield response to concentrate intake during early lactation and to assess the economic prospects ofExpand
Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient.
Cell-mediated autoimmune attack directed against islet proteins of approximately 38 kD in size has been associated with type 1 diabetes. A novel murine cDNA encoding an antigen of this size wasExpand