• Publications
  • Influence
Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.
Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has recently provided breakthrough progress in the treatment of melanoma, non-small cell lung cancer, and other types ofExpand
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Exfoliative Toxins of Staphylococcus aureus
Staphylococcus aureus is an important pathogen of humans and livestock. It causes a diverse array of diseases, ranging from relatively harmless localized skin infections to life-threatening systemicExpand
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Functional and structural characterization of Spl proteases from Staphylococcus aureus.
Staphylococcus aureus is the major cause of nosocomial infections world-wide, with increasing prevalence of community-acquired diseases. The recent dramatic increase in multi-antibiotic resistance,Expand
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Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells
Antibodies targeting the PD-1/PD-L1 immune checkpoint achieved spectacular success in anticancer therapy in the recent years. In contrast, no small molecules with cellular activity have been reportedExpand
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High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx
The Mdm2 and Mdmx proteins are the principal negative regulators of the p53 tumor suppressor. Reactivation of p53 activity by disrupting the Mdm2/Mdmx-p53 interactions offers new possibilities forExpand
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Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Blockade of the immunoinhibitory PD-1/PD-L1 pathway using monoclonal antibodies has shown impressive results with durable clinical antitumor responses. Anti-PD-1 and anti-PD-L1 antibodies have nowExpand
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Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73
The negative regulation of p53, a major human tumor suppressor, by Mdm2 and Mdmx is crucial for the survival of a cell, whereas its aberrant function is a common feature of cancer. Both Mdm proteinsExpand
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Molecular Cloning and Biochemical Characterisation of Proteases from Staphylococcus epidermidis
Abstract We report the complete coding sequence and the partial amino acid sequence (determined by chemical sequencing) of Staphylococcus epidermidis extracellular cysteine (Ecp) and serine (Esp)Expand
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Proteinaceous cysteine protease inhibitors
  • G. Dubin
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • 1 March 2005
Abstract.Studies of proteinaceous cysteine protease inhibitors originated with the discovery of cystatins in the 1960s. Since that time, a rich and fascinating world of proteins that control andExpand
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Extracellular Proteases of Staphylococcus spp.
  • G. Dubin
  • Biology, Medicine
  • Biological chemistry
  • 27 August 2002
Abstract Bacterial proteases secreted into an infected host may exhibit a wide range of pathogenic potentials. Staphylococci, in particular Staphylococcus aureus, are known to produce severalExpand
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