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Conserved structures and diversity of functions of RNA-binding proteins.
The major RNA-binding motifs are described and examples of how they may function are given.
A uniform system for microRNA annotation.
Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that mi RNAs can be reliably distinguished from other RNAs such as small interfering RNAs.
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
The SMG-1-mediated phosphorylation of Upf1 occurs on the association of SURF with EJC, which provides the link between the EJC and recognition of PTCs and triggers NMD.
hnRNP proteins and the biogenesis of mRNA.
The hnRNP Proteins Definition and Experimental Criteria and Posttranslational Modifications are described.
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs.
This work reports that Gemin3 and Gemin4 are also in a separate complex that contains eIF2C2, a member of the Argonaute protein family, which is a large approximately 15S RNP that contains numerous microRNAs (miRNAs).
Messenger-RNA-binding proteins and the messages they carry
From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger RNAs are associated with RNA-binding proteins that communicate crucial information to the translation machinery for the surveillance of nonsense mutations and for mRNA localization and translation.
A novel nuclear structure containing the survival of motor neurons protein.
It is found that SMN interacts with the RGG box region of hnRNP U, with itself, with fibrillarin and with several novel proteins, and monoclonal antibodies to the SMN protein are produced, report here on its striking cellular localization pattern.
RNA‐binding proteins and post‐transcriptional gene regulation
The Spinal Muscular Atrophy Disease Gene Product, SMN, and Its Associated Protein SIP1 Are in a Complex with Spliceosomal snRNP Proteins
RNA binding specificity of hnRNP A1: significance of hnRNP A1 high‐affinity binding sites in pre‐mRNA splicing.
UV light‐induced protein‐RNA crosslinking in nuclear extracts demonstrated that an oligoribonucleotide containing the A1 winner sequence can be used as a specific affinity reagent for hnRNP A1 and an unidentified 50 kDa protein, and it was shown that this oligoribia containing 5′ and 3′ pre‐mRNA splice sites are potent inhibitors of in vitro pre‐ mRNA splicing.