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Temporal Encoding of Place Sequences by Hippocampal Cell Assemblies
TLDR
It is found that temporal correlation between place cell pairs was stronger than predicted by a pacemaker drive of independent neurons, indicating a critical role for synaptic interactions and precise timing within and across cell assemblies in place sequence representation.
Organization of cell assemblies in the hippocampus
TLDR
Here it is found that the spike times of hippocampal pyramidal cells can be predicted more accurately by using the Spike times of simultaneously recorded neurons in addition to the animals location in space, suggesting that cell assemblies are synchronized at this timescale.
Preplay of future place cell sequences by hippocampal cellular assemblies
TLDR
It is reported that temporal sequences of firing of place cells expressed during a novel spatial experience occurred on a significant number of occasions during the resting or sleeping period preceding the experience.
Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells
TLDR
It is suggested that intrinsic properties of pyramidal cells have a key role in determining spike times, and that the interplay between the magnitude of dendritic excitation and rhythmic inhibition of the somatic region is responsible for the phase assignment of spikes.
Interactions between Hippocampus and Medial Septum during Sharp Waves and Theta Oscillation in the Behaving Rat
TLDR
Cross-correlated hippocampal sharp wave (SPW) ripples or theta activity and extracellular units recorded in the medial septum and diagonal band of Broca in freely moving rats indicate that the activity of medial sePTal neurons can be negatively (during SPW) or positively (during theta waves) correlated with theActivity of hippocampal interneurons.
Place Representation within Hippocampal Networks Is Modified by Long-Term Potentiation
TLDR
It is reported here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks, and the view that learned place representation can be accomplished by LTP-like synaptic plasticity within intrahippocampal networks is supported.
Distinct preplay of multiple novel spatial experiences in the rat
TLDR
These findings suggest that the place cell sequence of a novel spatial experience is determined, in part, by an online selection of a subset of cellular firing sequences from a larger repertoire of preexisting temporal firing sequences in the hippocampal cellular assembly network that become rapidly bound to the novel experience.
Hippocampal Pyramidal Cell–Interneuron Spike Transmission Is Frequency Dependent and Responsible for Place Modulation of Interneuron Discharge
TLDR
In the awake animal, interneurons were found that had place-modulated firing rates, with place maps similar to their presynaptic pyramidal neuron, indicating that single pyramsidal neurons can effectively determine the firing patterns of their interneuron targets.
Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective
TLDR
The presentation draws on computational neuroscience and pharmacologic and genetic studies in animals and humans to illustrate principles of network regulation that give rise to features of neural dysfunction associated with schizophrenia.
Homeostatic maintenance of neuronal excitability by burst discharges in vivo.
TLDR
It is proposed that the single spike versus burst competition presents a homeostatic regulatory mechanism to maintain synaptic strength and, consequently, firing rate in pyramidal cells.
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