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The G protein subunit gene families.
t i t u p g s t ( uch as neurotransmitters, hormones, and light. The vast ajority of such receptors are coupled to G proteins, which ransduce the signal to effectors. G proteins are heterotrimrs made… Expand
Supraspinal input is dispensable to generate glycine-mediated locomotive behaviors in the zebrafish embryo.
The anatomy of the developing zebrafish spinal cord is relatively simple but, despite this simplicity, it generates a sequence of three patterns of locomotive behaviors. The first behavior exhibited… Expand
Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability.
The enzyme acetylcholinesterase (AChE) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine. In addition, AChE is thought to play several… Expand
Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor beta-subunit.
- Hiromi Hirata, L. Saint-Amant, +4 authors J. Y. Kuwada
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 7 June 2005
Bilateral alternation of muscle contractions requires reciprocal inhibition between the two sides of the hindbrain and spinal cord, and disruption of this inhibition should lead to simultaneous… Expand
Gfap‐positive radial glial cells are an essential progenitor population for later‐born neurons and glia in the zebrafish spinal cord
Radial glial cells are presumptive neural stem cells (NSCs) in the developing nervous system. The direct requirement of radial glia for the generation of a diverse array of neuronal and glial… Expand
Structure and mapping of the G protein gamma3 subunit gene and a divergently transcribed novel gene, gng3lg.
The mammalian nervous system is rich in signaling mediated by heterotrimeric (alphabetagamma) G proteins. As an initial step to define the roles that particular gamma subunit types play in signaling,… Expand
prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements.
Proper functioning of the vertebrate central nervous system requires the precise positioning of many neuronal cell types. This positioning is established during early embryogenesis when gene… Expand
The G-Protein ? Complex
Abstract The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (αβγ) G proteins. Reviewed here is regulation of signal transduction by the βγ complex at different… Expand
Macondo crude oil from the Deepwater Horizon oil spill disrupts specific developmental processes during zebrafish embryogenesis
BackgroundThe Deepwater Horizon disaster was the largest marine oil spill in history, and total vertical exposure of oil to the water column suggests it could impact an enormous diversity of… Expand
Rapid in vivo labeling of identified zebrafish neurons
We report a simple and rapid method to label individual neurons in live zebrafish embryos and to examine their gene expression profiles. Injection of plasmid DNA encoding an α‐tubulin promotor… Expand