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Genome sequence of Yersinia pestis, the causative agent of plague
The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve.
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
The genome sequence is sequenced of a S. typhi (CT18) that is resistant to multiple drugs, revealing the presence of hundreds of insertions and deletions compared with the Escherichia coli genome, ranging in size from single genes to large islands.
Requirement of bic/microRNA-155 for Normal Immune Function
It is shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling, and suggests that bic-micro RNA-155 plays a key role in the homeostasis and function of the immune system.
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
We determined the complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain. Our analysis indicates that a large proportion (11%) of the genome consists…
Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa
IFITM3 restricts the morbidity and mortality associated with influenza
Data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans.
A novel EspA‐associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells
A novel EspA‐containing filamentous organelle is described that is present on the bacterial surface during the early stage of A/E lesion formation, forms a physical bridge between the bacterium and the infected eukaryotic cell surface and is required for the translocation of EspB into infected epithelial cells.
Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype.
Genome analysis of other epidemic ST313 isolates from Malawi and Kenya provided evidence for microevolution and clonal replacement in the field, including evidence of genome degradation, including pseudogene formation and chromosomal deletions, when compared with other S. Typhimurium genome sequences.
Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants.
This screen validated the hypothesis that the authors can simultaneously assay every gene in the genome to identify niche-specific essential genes and generate a genome-wide list of candidate essential genes.
Global dissemination of a multidrug resistant Escherichia coli clone
- Nicola K. Petty, Nouri L. Ben Zakour, S. Beatson
- BiologyProceedings of the National Academy of Sciences
- 31 March 2014
This study confirms the global dispersal of a single E. coli ST131 clone and demonstrates the role of MGEs and recombination in the evolution of this important MDR pathogen.