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Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome.
Sjögren syndrome (SS) is a systemic autoimmune disease characterized by dry mouth and eyes, and the cellular and molecular mechanisms for its pathogenesis are complex. Here we reveal, for the firstExpand
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Periodontal Ligament Stem Cell‐Mediated Treatment for Periodontitis in Miniature Swine
Periodontitis is a periodontal tissue infectious disease and the most common cause for tooth loss in adults. It has been linked to many systemic disorders, such as coronary artery disease, stroke,Expand
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Allogeneic Periodontal Ligament Stem Cell Therapy for Periodontitis in Swine
Periodontitis is one of the most widespread infectious diseases in humans. It is the main cause of tooth loss and associated with a number of systemic diseases. Until now, there is no appropriateExpand
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HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. HDAC6 is a transcriptional regulator of the histone deacetylase family, subfamily 2. Previous studies have shown that HDAC6Expand
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Why target PIM1 for cancer diagnosis and treatment?
The highly conserved proto-oncogenic protein PIM1 is an unusual serine or threonine kinase, in part because it is constitutively active. Overexpression of PIM1 experimentally leads to tumor formationExpand
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Effect of cryopreservation on biological and immunological properties of stem cells from apical papilla
Stem cells from apical papilla (SCAP) are a novel population of multipotent stem cells that, although similar to dental pulp stem cells, are a discrete source of dental stem cells. SCAP haveExpand
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Mesenchymal stem cells derived from inflamed periodontal ligaments exhibit impaired immunomodulation.
AIM The purpose of this study was to investigate the immunomodulatory properties of periodontal ligament stem cells derived from inflamed periodontal ligament tissues. MATERIAL AND METHODSExpand
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microRNA-21 mediates stretch-induced osteogenic differentiation in human periodontal ligament stem cells.
microRNAs (miRNAs) are short 20- to 22-nucleotide noncoding RNAs that negatively regulate the expression of target genes at the post-transcriptional level. The expression of specific miRNAs and theirExpand
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Periodontal Ligament Stem Cells Regulate B Lymphocyte Function via Programmed Cell Death Protein 1
Periodontal ligament stem cells (PDLSCs) have provided novel cell sources for tooth and periodontal tissue regeneration. Allogeneic PDLSCs can reconstruct periodontal ligament tissue that has beenExpand
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MiR-199a suppresses the hypoxia-induced proliferation of non-small cell lung cancer cells through targeting HIF1α
Deregulated microRNAs (miRNAs) are small noncoding RNAs that are involved in the carcinogenesis of various cancers, including lung cancer. HIF1α has been suggested to be a master regulator ofExpand
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