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Evaluation of the effect of food and specific gravity of tablets on gastric retention time
Abstract In the present study the effect of food and specific gravity on the gastric retention time of floating (spec. grav. 0.96) and non-floating (spec. grav. 1.59) tablet formulations was… Expand
Cross‐Linking of Gelatin Capsules and Its Relevance to Their in vitro‐ in vivo Performance
Cross-linking of gelatin capsules and its relevance to their in vitro-in vivo performance.
The present review deals with the chemistry of gelatin cross-linking under conditions that are relevant to pharmaceutical situations. Mechanistic rationalizations are offered to explain gelatin… Expand
Method for monitoring hard gelatin capsule disintegration times in humans using external scintigraphy.
Vaginal distribution of Replens and K-Y Jelly using three imaging techniques.
BACKGROUND Determination of vaginal distribution is important to the development of potential vaginal microbicidal or spermicidal products. STUDY DESIGN This was a descriptive study of three… Expand
Bioequivalence Study of Stressed and Nonstressed Hard Gelatin Capsules Using Amoxicillin as a Drug Marker and Gamma Scintigraphy to Confirm Time and GI Location of In Vivo Capsule Rupture
- G. Digenis, E. Sandefer, R. Page, W. Doll, T. Gold, N. Darwazeh
- Chemistry, Medicine
- Pharmaceutical Research
- 1 May 2000
AbstractPurpose: Evaluate if crosslinked hard gelatin capsules (HGCs) havingdifferent in vitro dissolution profiles changed in vivo release times oraltered bioavailability of a drug marker; assess if… Expand
Gamma scintigraphy: an evolving technology in pharmaceutical formulation development-Part 1
Abstract Gamma scintigraphy provides a noninvasive method to `see' the in vivo fate of a pharmaceutical dosage form. The power of the technique is realized fully by correlating deposition and transit… Expand
Evaluation of the Feasibility and Use of a Prototype Remote Drug Delivery Capsule (RDDC) for Non-Invasive Regional Drug Absorption Studies in the GI Tract of Man and Beagle Dog
AbstractPurpose. Evaluate a prototype Remote Drug Delivery Capsule (RDDC) for use in beagle dogs and human volunteers for non-invasive drug absorption studies in different regions of the… Expand
Disposition and metabolism of double-labeled [3H and 14C] N-methyl-2-pyrrolidinone in the rat.
The disposition of N-methyl-2-pyrrolidinone (NMP) was studied in the rat using tritium-labeled ([4-3H]NMP) and carbon-14-labeled ([methyl-14C]NMP and [ring-14C]NMP) radioisomers. Male Sprague-Dawley… Expand
Use of 99mTc-labeled triethylenetetramine-polystyrene resin for measuring the gastric emptying rate in humans.