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Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man
Chloride channels play important roles in the plasma membrane and in intracellular organelles. Mice deficient for the ubiquitously expressed ClC-7 Cl(-) channel show severe osteopetrosis and retinalExpand
Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols.
PURPOSE To define prognostic factors for response and long-term outcome for a wide spectrum of osteosarcomas, extending well beyond those of the typical young patient with seemingly localizedExpand
Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia.
  • Y. Li, A. Pirro, +4 authors M. Demay
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2 September 1997
Vitamin D, the major steroid hormone that controls mineral ion homeostasis, exerts its actions through the vitamin D receptor (VDR). The VDR is expressed in many tissues, including several tissuesExpand
Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols
PURPOSE: To define prognostic factors for response and long-term outcome for a wide spectrum of osteosarcomas, extending well beyond those of the typical young patient with seemingly localizedExpand
Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice.
1,25-Dihydroxyvitamin D3 plays a major role in intestinal calcium transport. To determine what phenotypic abnormalities observed in vitamin D receptor (VDR)-ablated mice are secondary to impairedExpand
Morphological grades of regression in osteosarcoma after polychemotherapy — Study COSS 80
SummaryThe histologic grade of regression of 50 osteosarcomas after polychemotherapy — according to the protocol study, COSS 80 — was classified on a six-stage regression scale; 56% of all patientsExpand
Osteosarcoma of the pelvis: experience of the Cooperative Osteosarcoma Study Group.
PURPOSE To define patients and tumor characteristics as well as therapy results, patients with pelvic osteosarcoma who were registered in the Cooperative Osteosarcoma Study Group (COSS) wereExpand
Long-term results of the co-operative German-Austrian-Swiss osteosarcoma study group's protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbs.
BACKGROUND In an effort to intensify osteosarcoma therapy, systemic ifosfamide was added pre- and postoperatively to an already aggressive three-drug regimen. In a subgroup of patients, loco-regionalExpand
The Gorham-Stout syndrome (Gorham's massive osteolysis). A report of six cases with histopathological findings.
The Gorham-Stout Syndrome (Gorham's massive osteolysis) is a rare condition in which spontaneous, progressive resorption of bone occurs. The aetiology is poorly understood. We report six cases of theExpand
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