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Insulin stimulates endothelin-1 secretion from human endothelial cells and modulates its circulating levels in vivo.
- C. Ferri, V. Pittoni, +7 authors A. Santucci
- Biology, MedicineThe Journal of clinical endocrinology and…
- 1 March 1995
The data show that insulin stimulates both in vitro and in vivo ET-1 secretion, suggesting that such interaction could play a significant role in the development of atherosclerotic lesions in hyperinsulinemic conditions.
Plasma Endothelin-1 Levels in Obese Hypertensive and Normotensive Men
It is shown that plasma ET-1 concentrations are increased in human obesity, which could depend on fasting insulin concentrations, abnormal peptide clearance, or both, and Hypertension does not influence the behavior of plasmaET-1 levels in obese men.
Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality.
The pathogenesis of antigen-specific antibodies in type 1 and type 2 diabetes is similar and probably involves a chronic nonrandom antigen-driven polyclonal B-cell activation that is consistent with a Th1-type immune response.
Effect of aldose reductase inhibition on glutathione redox status in erythrocytes of diabetic patients.
Endogenous Insulin Modulates Circulating Endothelin-1 Concentrations in Humans
This study indicates that significant changes in circulating ET-1 levels occur after oral glucose loading, probably due to a glucose-induced increment in endogenous insulin concentration.
Effect of ACE Inhibition on Spontaneous and Insulin-Stimulated Endothelin-1 Secretion: In Vitro and In Vivo Studies
In vivo, captopril inhibits both spontaneous and insulinstimulated ET-1 secretion by endothelial cells, acting on angiotensin-converting enzyme bound to the luminal cell side, as well as in vitro and in vivo.
Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients.
Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients.
Early upregulation of endothelial adhesion molecules in obese hypertensive men.
It is shown that obesity per se induces early endothelial activation in hypertensive and normotensive men and weight loss counteracted endothelialactivation in both obese hypertensive or normotense men.
Angiotensin II increases the release of endothelin-1 from human cultured endothelial cells but does not regulate its circulating levels.
The findings indicate that angiotensin II regulates endothelin-1 release by cultured endothelial cells through an AT1 receptor-dependent pathway, but does not influence circulating endothelins-1 levels in vivo.