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Early social attention impairments in autism: social orienting, joint attention, and attention to distress.
TLDR
Combined impairments in joint attention and social orienting were found to best distinguish young children with ASD from those without ASD and structural equation modeling indicated that joint attention was the best predictor of concurrent language ability.
View on PubMed
Functional impact of global rare copy number variation in autism spectrum disorders
TLDR
The genome-wide characteristics of rare (<1% frequency) copy number variation in ASD are analysed using dense genotyping arrays to reveal many new genetic and functional targets in ASD that may lead to final connected pathways.
View on Nature
Early recognition of children with autism: A study of first birthday home videotapes
Coded home videotapes of 11 autistic and 11 normally developing children's first year birthday parties for social, affective, joint attention, and communicative behaviors and for specific autistic…
View on Springer
Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder
  • G. Dawson
  • Psychology, Biology
    Development and Psychopathology
  • 1 June 2008
TLDR
A developmental model of risk, risk processes, symptom emergence, and adaptation in ASD is described that offers a framework for understanding early brain plasticity in ASD and its role in prevention of the disorder.
View on Cambridge Press
Synaptic, transcriptional, and chromatin genes disrupted in autism
TLDR
Using exome sequencing, it is shown that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes at a false discovery rate of < 0.05, plus a set of 107 genes strongly enriched for those likely to affect risk (FDR < 0.30).
View on Nature
The screening and diagnosis of autistic spectrum disorders.
TLDR
Specific detailed recommendations for each level have been established in this document, which are intended to improve the rate of early suspicion and diagnosis of, and therefore early intervention for, autism.
View on PubMed
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
TLDR
Several new susceptibility genes encoding neuronal cell-adhesion molecules, including NLGN1 and ASTN2, were enriched with CNVs in ASD cases compared to controls, and duplications 55 kilobases upstream of complementary DNA AK123120 indicate that these two important gene networks expressed within the central nervous system may contribute to the genetic susceptibility of ASD.
View on Nature
Brain structural abnormalities in young children with autism spectrum disorder
TLDR
Structural findings suggest abnormal brain developmental processes early in the clinical course of autism, and research currently is underway to better elucidate mechanisms underlying mechanisms underlying these structural abnormalities and their longitudinal progression.
View on Wolters Kluwer
Common genetic variants on 5p14.1 associate with autism spectrum disorders
TLDR
The results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to the authors' knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs.
View on Nature
Practice parameter: Screening and diagnosis of autism
TLDR
This approach requires a dual process: 1) routine developmental surveillance and screening specifically for autism to be performed on all children to first identify those atrisk for any type of atypical development, and to identify those specifically at risk for autism.
View on Wolters Kluwer
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