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Indicators of socioeconomic position (part 1)
This glossary presents a comprehensive list of indicators of socioeconomic position used in health research. A description of what they intend to measure is given together with how data are elicitedExpand
Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational prospective observational study investigating influences on health and development across the life course and is currently set up as a supported access resource. Expand
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
An adaption of Egger regression can detect some violations of the standard instrumental variable assumptions, and provide an effect estimate which is not subject to these violations, and provides a sensitivity analysis for the robustness of the findings from a Mendelian randomization investigation. Expand
Mendelian randomization: using genes as instruments for making causal inferences in epidemiology.
The use of germline genetic variants that proxy for environmentally modifiable exposures as instruments for these exposures is one form of IV analysis that can be implemented within observational epidemiological studies and can be considered as analogous to randomized controlled trials. Expand
The MR-Base platform supports systematic causal inference across the human phenome
MR-Base is a platform that integrates a curated database of complete GWAS results (no restrictions according to statistical significance) with an application programming interface, web app and R packages that automate 2SMR, and includes several sensitivity analyses for assessing the impact of horizontal pleiotropy and other violations of assumptions. Expand
Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
Summary The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents andExpand
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
A novel weighted median estimator for combining data on multiple genetic variants into a single causal estimate is presented, which is consistent even when up to 50% of the information comes from invalid instrumental variables. Expand
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
Developments of MR, including two-sample MR, bidirectional MR, network MR, two-step MR, factorial MR and multiphenotype MR, are outlined in this review. Expand
Statins for the primary prevention of cardiovascular disease.
Reductions in all-cause mortality, major vascular events and revascularisations were found with no excess of adverse events among people without evidence of CVD treated with statins, and evidence available to date showed that primary prevention with statin is likely to be cost-effective and may improve patient quality of life. Expand
Indicators of socioeconomic position (part 2)
This is the second part of a glossary on indicators of socioeconomic position used in health research published in the January issue of the journal Health Affairs. Expand