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Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational prospective observational study investigating influences on health and development across the life course. ItExpand
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Indicators of socioeconomic position (part 1)
This glossary presents a comprehensive list of indicators of socioeconomic position used in health research. A description of what they intend to measure is given together with how data are elicitedExpand
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Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
Background: The number of Mendelian randomization analyses including large numbers of genetic variants is rapidly increasing. This is due to the proliferation of genome-wide association studies, andExpand
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Mendelian randomization: using genes as instruments for making causal inferences in epidemiology.
Observational epidemiological studies suffer from many potential biases, from confounding and from reverse causation, and this limits their ability to robustly identify causal associations. SeveralExpand
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Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
Summary The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents andExpand
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Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
Developments in genome‐wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization relatively straightforward.Expand
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The MR-Base platform supports systematic causal inference across the human phenome
Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SMR) and bypassing theExpand
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Mendelian randomization: genetic anchors for causal inference in epidemiological studies
Observational epidemiological studies are prone to confounding, reverse causation and various biases and have generated findings that have proved to be unreliable indicators of the causal effects ofExpand
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Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis.
CONTEXT Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke. OBJECTIVE To assess the relationships of fibrinogen levels with risk of major vascularExpand
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Education and occupational social class: which is the more important indicator of mortality risk?
STUDY OBJECTIVES: In the UK, studies of socioeconomic differentials in mortality have generally relied upon occupational social class as the index of socioeconomic position, while in the US, measuresExpand
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