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Thermal and pharmacological characterization of some new bis-xanthine derivatives
Abstract The 8-substituted bis-xanthine derivatives with various substituents have been synthesized taking in the view the previous results with xanthine derivatives, exhibiting enhanced and… Expand
Antioxidant action of a new flavonic derivative in acute carbon tetrachloride intoxication
- I. Păduraru, A. Saramet, +5 authors M. Filip
- Chemistry, Medicine
- European Journal of Drug Metabolism and…
Results suggest that TR-1722 acts by curtailing both lipid peroxidation and alkylation processes, using CCl4 as a free radical generating model. Expand
Thermal characterization of some new xanthine derivatives
Abstract In order to enhance and multiply the pharmacological properties of theophylline, the 8-substituted-7-[2-hydroxy-3-(4-acetyl-amino)-fenoxy-propyl]-1,3-dimethyl-xanthine derivatives with… Expand
Direct detection of the antioxidant activity of a new flavonic derivative using the chemiluminescence method.
- A. Saramet, G. Danila, I. Păduraru, D. Petrariu, R. Olinescu
- Chemistry, Medicine
- 1 May 1996
The results obtained reveal that theophylline rutoside (TR-1722) has antioxidant action comparable to that of quercetin, the highest efficacity being registered at the concentration of 2 mumol/l, the conditions being: H2O2 16,2 mmol/l; luminol 2 mumoled; Tris-HCl buffer 20 mmol/L, pH 8.3. Expand
[Derivatives of 2-thion-3-isonicotinoylamino-thiazolid-4-one with tuberculostatic activity].
The influence of magnesium, chromium and copper in alloxan-induced diabetic rats.
[The mechanisms of action of etophylline-clofibrate in hyperlipidemia].
[Study of the cardiovascular properties of some new methyl-xanthine derivatives].
The effects of some new methylxanthine compounds, derivatives of theophylline, theobromine and caffeine with various radicals in 8 position on blood pressure have been studied. Derivatives of… Expand
[Interactions between prostaglandins and 1,3-dimethylxanthine derivatives].
[An update and the outlook in the prevention and treatment of diabetic complications].
- G. Danila
- Revista medico-chirurgicala a Societatii de…