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The petite mutation in yeasts: 50 years on.
A review of the early work on cytoplasmic inheritance is presented together with some observations on current developments to address the questions of how loss of mtDNA leads to lethality (rho 0-lethality) in petite-negative yeasts and how S. cerevisiae tolerates elimination of mt DNA.
Rolling circle replication of DNA in yeast mitochondria.
The conformation of mitochondrial DNA from yeasts has been examined and the presence of lariats, together with the observation that the majority of mtDNA is linear and 2–7 genome units in length, suggests that replication occurs by a rolling circle mechanism.
Evolution of mitochondrial genomes in fungi.
- G. D. Clark-Walker
- Biology, MedicineInternational review of cytology
Sizes, gene topology, and structures contributing to size variation of mitochondrial DNA (mtDNAs) in fungi are described and mechanisms for generating length mutations and rearrangements together with a description of mtDNA codon variations are presented.
α and β subunits of F1-ATPase are required for survival of petite mutants in Saccharomyces cerevisiae
It is shown that a function associated with the F1-ATPase, which is distinct from its role in energy transduction, is required for the petite-positive phenotype of S. cerevisiae.
Mitochondrial DNA of the coral sarcophyton glaucum contains a gene for a homologue of bacterial muts: A possible case of gene transfer from the nucleus to the mitochondrion
- G. Pont-Kingdon, N. Okada, +5 authors D. Wolstenholme
- Biology, MedicineJournal of Molecular Evolution
- 1 April 1998
The phylogenetic analysis of MutS family protein sequences indicates that the S. glaucum mtMSH protein is more closely related to the nuclear DNA-encoded mitochondrial mismatch repair protein (MSH1) of the yeast Saccharomyces cerevisiae than to eukaryotic homologue involved in nuclear function, or to bacterial homologues.
MGM101, a nuclear gene involved in maintenance of the mitochondrial genome in Saccharomyces cerevisiae.
Creation of a null mutant by targeted disruption showed that the corresponding gene, MGM101, has no essential cellular function, aside from its participation in mitochondrial genome maintenance.
RRP20, a component of the 90S preribosome, is required for pre-18S rRNA processing in Saccharomyces cerevisiae.
- S. Senapin, G. D. Clark-Walker, Xin Jie Chen, B. Séraphin, M. Daugeron
- Biology, MedicineNucleic acids research
- 15 May 2003
A strain of Saccharomyces cerevisiae, defective in small subunit ribosomal RNA processing, has a mutation in YOR145c ORF that converts Gly235 to Asp, which causes a marked deficiency in 18S rRNA production and is renamed as RRP20.
Yeasts have a four‐fold variation in ribosomal DNA copy number
By employing pulsed‐field gel electrophoresis we have determined the size of the rDNA cluster in wild‐type yeast strains representing genera of Candida, Kluyveromyces, Pachysolen, Schizosaccharomyces…
Studying mitochondria in an attractive model: Schizosaccharomyces pombe.
- Stéphane Chiron, M. Gaisne, E. Guillou, P. Belenguer, G. D. Clark-Walker, N. Bonnefoy
- Biology, MedicineMethods in molecular biology
This technical review briefly lists the general and specific properties that are helpful to know when starting to use fission yeast as a model system for mitochondrial studies.
Positive and Negative Control of Multidrug Resistance by the Sit4 Protein Phosphatase in Kluyveromyces lactis *
- X. J. Chen, B. Bauer, K. Kuchler, G. D. Clark-Walker
- Biology, MedicineThe Journal of Biological Chemistry
- 19 May 2000
Overexpression of SIT4 leads to an elevation in resistance to paromomycin and to lesser extent tolerance to sorbic acid, but it has no detectable effect on resistance to 4-NQO.