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Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium
- G. D. Block, J. Locker, +6 authors G. Michalopoulos
- Biology, Medicine
- The Journal of cell biology
- 2 March 1996
The hypothesis that mature hepatocytes can function as or be a source of bipotential facultative hepatic stem cells (hepatoblasts) is supported and evidence for the growth factor and matrix signals that govern these complex phenotypic transitions of facultative stem cells are provided. Expand
Association of acetaminophen hepatotoxicity with fasting and ethanol use.
Acetaminophen hepatotoxicity after an overdose appears to be enhanced by fasting in addition to alcohol ingestion, and was associated with fasting and less commonly with alcohol use. Expand
Reduction of renal calcium reabsorption in man by consumption of dietary protein.
It is concluded that protein consumption reduces the amount of calcium reabsorbed by the kidney. Expand
Novel Bioartificial Liver Support System: Preclinical Evaluation
- J. Patzer, G. Mazariegos, +14 authors B. Amiot
- Annals of the New York Academy of Sciences
- 1 June 1999
The results suggest the novel BLSS reported here can have a significant impact on the course of liver failure in the d‐galactosamine canine liver failure model and is ready for Phase I safety evaluation in a clinical setting. Expand
Organophosphate poisoning in office workers.
- M. Hodgson, G. D. Block, D. Parkinson
- Journal of occupational medicine. : official…
- 1 June 1986
Recovery of erythrocyte cholinesterase levels occurred during the subsequent three months but followed an exponential distribution rather than the constant rate of recovery most investigators have assumed. Expand
A comparison of the effects of feeding sulfur amino acids and protein on urine calcium in man.
- G. D. Block, R. Wood, L. Allen
- Chemistry, Medicine
- The American journal of clinical nutrition
- 1 October 1980
Compared to the control, the high protein diet caused an increase in urinary calcium and sulfate and a decrease in the renal reabsorption of calcium, and the sulfur amino acid supplement had no effect on calcium excretion or re absorption. Expand
The role of insulin and parathyroid hormone in the protein-induced calciuria of man
The consumption of dietary protein has been shown to increase urinary calcium due to a reduction in the renal tubular reabsorption of calcium. This experiment was designed to examine the postprandial… Expand
D-galactosamine based canine acute liver failure model.
- J. Patzer, G. D. Block, +10 authors G. Mazariegos
- Hepatobiliary & pancreatic diseases international…
- 1 August 2002
The improved lethal canine liver failure model presented here reproduces many of the clinical features of acute liver failure and may prove useful for qualitative and quantitative evaluation of BALs. Expand
Effect of Growth Factors and Defined Medium on Primary Hepatocyte Culture on Polyester Carriers with Varying Surface Treatment
The growth and function of primary rat hepatocytes was characterized on commercial, electrostatically treated nonwoven polyester carriers (Fibra-Cel) designed for use in a packed-bed bioreactor to initiate investigations of the potential of these carriers for hepatocyte support. Expand
PRECLINICAL EVALUATION OF A NOVEL BIOARTIFICIAL LIVER USING A CANINE D-GALACOSAMINE LIVER FAILURE MODEL