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Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome X-like alterations in adulthood of neonatally overfed rats
Overnutrition during critical developmental periods is suggested to be a risk factor for obesity and associated metabolic disorders in later life. Underlying mechanisms are unknown. Neuropeptides areExpand
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Morphological alterations of hypothalamic nucleidue to intrahypothalamic hyperinsulinism in newborn rats
In former studies, a temporary, intrahypothalamically localized hyperinsulinism duringbrain development was shown to result in overweight and metabolic disturbances during later lifein rats.Expand
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Obesity and enhanced diabetes and cardiovascular risk in adult rats due to early postnatal overfeeding.
To investigate possible permanent consequences of an early postnatal overfeeding, the following experimental model was used: Male Wistar rats were divided into three groups after birth: (1) SmallExpand
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Glucose tolerance and insulin secretion in children of mothers with pregestational IDDM or gestational diabetes
Summary The offspring of mothers with diabetes mellitus during pregnancy are presumed to develop altered glucose homeostasis. We analysed metabolic parameters at birth and glucose tolerance andExpand
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Hypothalamic nuclei are malformed in weanling offspring of low protein malnourished rat dams.
Maternal low protein malnutrition during gestation and lactation (LP) is an animal model frequently used for the investigation of long-term deleterious consequences of perinatal growth retardation.Expand
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Hormones and brain differentiation
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Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life.
The importance of the intrauterine and neonatal metabolic environment as possible teratogenic determinants of predispositions to diabetes, obesity and cardiovascular diseases is discussed.Expand
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Overweight and obesity in infants of mothers with long-term insulin-dependent diabetes or gestational diabetes
OBJECTIVES: To analyse the development of body weight and frequencies of overweight and obesity in infants of long-term insulin-dependent diabetic mothers as compared to those of gestational diabeticExpand
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Malformations of Hypothalamic Nuclei in Hyperinsulinemic Offspring of Rats with Gestational Diabetes
Insulin is a potent modulator of central nervous development and is suggested to influence the differentiation and maturation of hypothalamic structures involved in the regulation of body weight andExpand
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Neuroendocrine response to estrogen and brain differentiation in heterosexuals, homosexuals, and transsexuals
  • G. Dörner
  • Psychology, Medicine
  • Archives of sexual behavior
  • 1 February 1988
Since 1964, we have found positive estrogen feedback to be a relatively sex-specific reaction of the hypothalamo-hypophyseal system in rats as well as in human beings. It is dependent on theExpand
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