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Antioxidant and cytoprotective properties of high-density lipoproteins in vascular cells.
Beside their key role in the regulation of cholesterol homeostasis, HDL exhibit antioxidant and anti-inflammatory properties that participate to their general antiatherogenic effect. The purpose ofExpand
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Glycated low density lipoproteins modify platelet properties: a compositional and functional study.
The interaction between low density lipoproteins (LDL) and platelets might play a central role in the development of atherosclerosis in diabetes. The aim of the present study was to investigateExpand
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Effect of glycation of high density lipoproteins on their physicochemical properties and on paraoxonase activity
Abstract We investigated the effect of incubation of high density lipoprotein (HDL) under hyperglycaemic conditions on lipid composition, physicochemical properties and activity of paraoxonase (PON),Expand
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Structural modifications of HDL and functional consequences.
High density lipoproteins (HDL) are susceptible to structural modifications mediated by various mechanisms including oxidation, glycation, homocysteinylation or enzymatic degradation. StructuralExpand
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Protective effect of paraoxonase activity in high-density lipoproteins against erythrocyte membranes peroxidation: a comparison between healthy subjects and type 1 diabetic patients.
High-density lipoproteins (HDL) plays a key role in the protection against oxidative damage of lipoprotein and biological membranes. The aim of the present study was to investigate the relationshipExpand
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Reduced Na+ -K+ -ATPase Activity and Plasma Lysophosphatidylcholine Concentrations in Diabetic Patients
A fraction from normal human plasma inhibiting Na+ -K+ ATPase has been recently identified as lysophosphatidylcholine (LPC). The aim of this study was to investigate the existence of a relationshipExpand
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Effect of homocysteinylation of low density lipoproteins on lipid peroxidation of human endothelial cells
Homocysteine‐thiolactone (HcyT) is a toxic product whose synthesis is directly proportional to plasma homocysteine (Hcy) levels. Previous studies demonstrated that the interaction between HcyT andExpand
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Copper-induced oxidative damage on astrocytes: protective effect exerted by human high density lipoproteins.
In the present study, we confirmed that copper ions induce oxidative damage in human astrocytes in culture, as demonstrated by the significant increase in the levels of hydroperoxides and in theExpand
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Modification induced by homocysteine and low-density lipoprotein on human aortic endothelial cells: an in vitro study.
The aim of the present study was to investigate the effect exerted by low-density lipoprotein (LDL) modified by homocysteine (Hcy)-thiolactone (Hcy-LDL) on functional properties on human endothelialExpand
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Effect of genistein against copper-induced lipid peroxidation of human high density lipoproteins (HDL).
Several studies have demonstrated that the isoflavone genistein exerts a protective effect against lipid peroxidation of low density lipoproteins (LDL). Aim of our study was to investigate whetherExpand
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