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Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis.
- G. Cunnane, O. FitzGerald, C. Beeton, T. Cawston, B. Bresnihan
- Arthritis and rheumatism
- 1 October 2001
OBJECTIVE To further evaluate the roles of matrix metalloproteinase 1 (MMP-1), MMP-3, and tissue inhibitor of metalloproteinases 1 (TIMP-1) in the pathogenesis of joint inflammation and articular… Expand
Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis.
BACKGROUND: Hypersensitivity drug reactions cause a variety of skin diseases including bullous and pustular eruptions and maculopapular exanthema (MPE). Knowledge of the underlying pathological… Expand
Serum amyloid A in the assessment of early inflammatory arthritis.
OBJECTIVE Acute phase serum amyloid A (A-SAA) has been reported to be more sensitive than C-reactive protein (CRP) as a marker of disease activity. It may function in immune regulation and is linked… Expand
Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis.
OBJECTIVE To relate the expression of proteases in the lining and sublining layers of the synovial membrane to the rate of joint damage during 1 year in patients with early inflammatory arthritis. … Expand
The association of cytokines with disease activity and damage scores in systemic lupus erythematosus patients.
OBJECTIVE The aim of this study was to explore the role of cytokines in the pathogenesis of SLE in a genetically homogeneous Caucasian SLE patient population. METHODS Serum levels of the following… Expand
Increased Body Mass Index in Ankylosing Spondylitis Is Associated with Greater Burden of Symptoms and Poor Perceptions of the Benefits of Exercise
- L. Durcan, Fiona Wilson, R. Conway, G. Cunnane, F. O’Shea
- The Journal of Rheumatology
- 1 December 2012
Objective. Increased body mass index (BMI) in patients with ankylosing spondylitis (AS) is associated with a greater burden of symptoms and poor perceptions of the benefits of exercise. In AS, the… Expand
Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis.
OBJECTIVE To examine the expression of the matrix metalloproteinase, MMP-1, and the cysteine proteases, cathepsin B (CB) and cathepsin L (CL), in the synovial membrane (SM) of patients with early… Expand
Microscopic measurement of synovial membrane inflammation in rheumatoid arthritis: proposals for the evaluation of tissue samples by quantitative analysis.
- B. Bresnihan, G. Cunnane, P. Youssef, G. Yanni, O. FitzGerald, D. Mulherin
- British journal of rheumatology
- 1 June 1998
Previous studies have used various techniques for microscopic analysis of rheumatoid synovium, ranging from rapid analysis of limited areas of tissue to detailed quantification of extensive areas.… Expand
Amyloid precursors and amyloidosis in inflammatory arthritis.
- G. Cunnane
- Current opinion in rheumatology
Recent data demonstrating the multifunctional role of serum amyloid A (SAA) in the pathogenesis of amyloidosis have yielded important insights into this potentially fatal consequence of chronic… Expand
Immunohistologic analysis of peripheral joint disease in ankylosing spondylitis.