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Prostate cancer in a transgenic mouse.
Progress toward understanding the biology of prostate cancer has been slow due to the few animal research models available to study the spectrum of this uniquely human disease. To develop an animalExpand
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Roles for Nkx3.1 in prostate development and cancer.
In aging men, the prostate gland becomes hyperproliferative and displays a propensity toward carcinoma. Although this hyperproliferative process has been proposed to represent an inappropriateExpand
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The endocrinology and developmental biology of the prostate.
I. Introduction MALE accessory sex glands such as the prostate, seminal vesicle, and bulbourethral gland have served in various capacities as models for investigating the action of androgens inExpand
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Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1
SummaryThis report describes the development and characterization of an epithelial cell line (BPH-1) from human prostate tissue obtained by transurethral resection. Primary epithelial cell culturesExpand
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Morphogenesis of ductal networks in the mouse prostate.
Postnatal growth and development of the glandular architecture of the ventral and dorsolateral lobes of the mouse prostate (VP and DLP) were investigated by microdissection techniques that permittedExpand
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Hormonal, cellular, and molecular control of prostatic development.
The prostate is a male accessory sex gland found only in mammals that functions to produce a major fraction of seminal fluid. Interest in understanding the biology of the prostate is driven both byExpand
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Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium.
Estradiol-17beta (E2) acts through the estrogen receptor (ER) to regulate uterine growth and functional differentiation. To determine whether E2 elicits epithelial mitogenesis through epithelial ERExpand
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Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer.
The transgenic adenocarcinoma of mouse prostate (TRAMP) model is widely used in prostate cancer research because of rapid tumor onset and progression. The transgenic mouse is on a C57BL/6 (B6)Expand
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Role of the stromal microenvironment in carcinogenesis of the prostate
The topic of this review is the role of stromal‐epithelial interactions in normal and malignant prostatic growth. Because cell‐cell interactions and androgens play such key roles in the prostate, theExpand
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Role of stroma in carcinogenesis of the prostate.
Prostatic development is induced by androgens acting via mesenchymal-epithelial interactions. Androgens elicit their morphogenetic effects by acting through androgen receptors (ARs) in urogenitalExpand
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