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Prostate cancer in a transgenic mouse.
TLDR
The establishment of breeding lines of transgenic mice that reproducibly develop prostate cancer provides an animal model system to study the molecular basis of transformation of normal prostatic cells and the factors influencing the progression to metastatic prostate cancer.
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Roles for Nkx3.1 in prostate development and cancer.
TLDR
It is shown that the murine Nkx3.1 homeobox gene is the earliest known marker of prostate epithelium during embryogenesis and is subsequently expressed at all stages of prostate differentiation in vivo as well as in tissue recombinants.
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The endocrinology and developmental biology of the prostate.
TLDR
The most extensively studied gland of this group is the prostate, which is found exclusively in mammals and produces many components of semen such as fructose, zinc ions, and various proteins important for the formation of the copulatory plug in rodents.
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Hormonal, cellular, and molecular control of prostatic development.
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Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1
TLDR
The development and characterization of an epithelial cell line (BPH-1) from human prostate tissue obtained by transurethral resection, which expresses the SV40 large T antigen and exhibits increased levels of p53, as determined by immunocytochemistry.
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Morphogenesis of ductal networks in the mouse prostate.
TLDR
Ducts of the lateral prostate (LP), a ventrolateral subdivision of the DLP, initiated branching morphogenesis between 1 to 5 days after birth and the LP grew into and became embedded within the capsule of the VP, which may explain why the ductal architecture of these two lobes are similar.
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Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development
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Cell differentiation lineage in the prostate.
TLDR
It is proposed that at all stages (embryonic to adult) prostatic epithelial progenitor/stem cells maintain a differentiation marker profile similar to that of the original embryonic progenitors of the prostate, namely urogenital sinus epithelium.
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Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer.
TLDR
The transgenic adenocarcinoma of mouse prostate (TRAMP) model is widely used in prostate cancer research because of rapid tumor onset and progression, and neuroendocrine carcinomas are the principal malignancy in this model.
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Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium.
TLDR
It is demonstrated that epithelial ER is neither necessary nor sufficient for E2-induced uterine epithelial proliferation, and similar studies in the prostate suggest that epitheric mitogenesis in both estrogen and androgen target organs are stromally mediated events.
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