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Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
CCR5 is the major HIV-1 co-receptor, and individuals homozygous for a 32-bp deletion in CCR5 are resistant to infection by CCR5-tropic HIV-1. Using engineered zinc-finger nucleases (ZFNs), weExpand
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Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells
Our understanding of how mesodermal tissue is formed has been limited by the absence of specific and reliable markers of early mesoderm commitment. We report that mesoderm commitment from humanExpand
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A functional comparison of CD34 + CD38- cells in cord blood and bone marrow.
We present cell cycling and functional evidence that the CD34+CD38- immunophenotype can be used to define a rare and primitive subpopulation of progenitor cells in umbilical cord blood. CD34+CD38-Expand
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Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors.
We compared the efficiency of transduction by an HIV-1-based lentiviral vector to that by a Moloney murine leukemia virus (MLV) retroviral vector, using stringent in vitro assays of primitive,Expand
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Identification of a novel, human multilymphoid progenitor in cord blood.
The earliest stages of lymphoid commitment from human pluripotent hematopoietic stem cells have not been defined. A clonogenic subpopulation of CD34(+)CD38(-) cord blood cells were identified thatExpand
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A CD133‐Expressing Murine Liver Oval Cell Population with Bilineage Potential
Although oval cells are postulated to be adult liver stem cells, a well‐defined phenotype of a bipotent liver stem cell remains elusive. The heterogeneity of cells within the oval cell fraction hasExpand
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Distinct homeostatic requirements of CD4+ and CD4- subsets of Valpha24-invariant natural killer T cells in humans.
CD1d-restricted Valpha24-invariant natural killer T cells (iNKTs) are important in immunoregulation. CD4(+) and CD4(-) iNKTs develop with similar frequencies in murine thymus and depend onExpand
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Lymphoid priming in human bone marrow begins before expression of CD 10 with upregulation of L-selectin
Although much is known about the identity of progenitor stages in mouse lymphopoiesis, considerably less is understood about the critical stages of lymphoid commitment of human hematopoietic cells.Expand
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Engraftment of gene–modified umbilical cord blood cells in neonates with adenosine deaminase deficiency
Haematopoietic stem cells in umbilical cord blood are an attractive target for gene therapy of inborn errors of metabolism. Three neonates with severe combined immunodeficiency were treated byExpand
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Perivascular support of human hematopoietic stem/progenitor cells.
Hematopoietic stem and progenitor cells (HSPCs) emerge and develop adjacent to blood vessel walls in the yolk sac, aorta-gonad-mesonephros region, embryonic liver, and fetal bone marrow. In adultExpand
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