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Ankyrin-Based Subcellular Gradient of Neurofascin, an Immunoglobulin Family Protein, Directs GABAergic Innervation at Purkinje Axon Initial Segment
Distinct classes of GABAergic synapses are segregated into subcellular domains (i.e., dendrite, soma, and axon initial segment-AIS), thereby differentially regulating the input, integration, andExpand
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GAD67-Mediated GABA Synthesis and Signaling Regulate Inhibitory Synaptic Innervation in the Visual Cortex
The development of GABAergic inhibitory circuits is shaped by neural activity, but the underlying mechanisms are unclear. Here, we demonstrate a novel function of GABA in regulating GABAergicExpand
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Development of GABA innervation in the cerebral and cerebellar cortices
In many areas of the vertebrate brain, such as the cerebral and cerebellar cortices, neural circuits rely on inhibition mediated by GABA (γ-aminobutyric acid) to shape the spatiotemporal patterns ofExpand
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Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs
Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanismExpand
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Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity
Functional maturation of GABAergic innervation in the developing visual cortex is regulated by neural activity and sensory inputs and in turn influences the critical period of ocular dominanceExpand
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GABAergic Circuit Dysfunctions in Neurodevelopmental Disorders
GABAergic interneurons control neuronal excitability, integration, and plasticity. Further, they regulate the generation of temporal synchrony and oscillatory behavior among networks of pyramidalExpand
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KCC2, epileptiform synchronization, and epileptic disorders
The K+-Cl- co-transporter KCC2 is a neuron-specific, Cl- extruder that uses K+ gradient for maintaining low intracellular [Cl-]. It is indeed well established that sustaining an outwardly-directedExpand
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Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders
GABAergic interneurons powerfully control the function of cortical networks. In addition, they strongly regulate cortical development by modulating several cellular processes such as neuronalExpand
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Time to Change: Retina Sends a Messenger to Promote Plasticity in Visual Cortex
Maturation of GABA inhibitory circuitry in primary visual cortex activates the critical period of plasticity, but the underlying mechanisms are not well understood. In the August 8th issue of Cell,Expand
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Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures
Atypical febrile seizures are considered a risk factor for epilepsy onset and cognitive impairments later in life. Patients with temporal lobe epilepsy and a history of atypical febrile seizuresExpand
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