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Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
View on Elsevier
Astrocyte scar formation aids central nervous system axon regeneration
TLDR
Interestingly, RNA sequencing revealed that astrocytes and non-astrocyte cells in SCI lesions express multiple axon-growth-supporting molecules, showing that contrary to the prevailing dogma, astroCyte scar formation aids rather than prevents central nervous system axon regeneration.
View on Nature
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
TLDR
Broad neuroprotective effects of entorhinal brain-derived neurotrophic factor administration in several animal models of Alzheimer's disease are shown, with extension of therapeutic benefits into the degenerating hippocampus.
View on Nature
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence
View on Elsevier
Human-Specific Transcriptional Regulation of CNS Development Genes by FOXP2
TLDR
Experimental support is provided for the functional relevance of changes in FOXP2 that occur on the human lineage, highlighting specific pathways with direct consequences for human brain development and disease in the central nervous system (CNS).
View on Nature
Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
View on Elsevier
Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization.
TLDR
Genome-wide microarray analysis reveals that a previously unappreciated number of transcripts are localized in sensory axons and that this repertoire changes during development toward adulthood, leading to the first complete catalog of embryonic and adult sensory axonal mRNAs.
View on PubMed
Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice
TLDR
Proteomics was used to confirm 790 genes and 5 striatal modules with CAG length–dependent dysregulation at the protein level, and validated 22 striatal module genes as modifiers of mHtt toxicities in vivo.
View on Nature
Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain.
TLDR
These data provide the first insight into the functional network of genes directly regulated by FOXP2 in human brain and by evolutionary comparisons, highlighting genes likely to be involved in the development of human higher-order cognitive processes.
View on PubMed
Incidence and impact of subclinical epileptiform activity in Alzheimer's disease
TLDR
Higher than expected rates of subclinical epileptiform activity in AD with deleterious effects on cognition are hypothesized, motivated by results from animal studies.
View on Wiley
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