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  • Influence
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice.
TLDR
Adiponectin was effective in ameliorating hepatomegaly, steatosis, and alanine aminotransferase abnormality associated with nonalcoholic obese, ob/ob mice and could suppress the hepatic production of TNF-alpha and plasma concentrations of this proinflammatory cytokine. Expand
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.
TLDR
A peptide, of calculated molecular mass 3905 Da, that was a major protein component of amyloid-rich pancreatic extracts of three type 2 diabetic patients is described, indicating that these peptides are related in evolution. Expand
Adiponectin Inhibits Cell Proliferation by Interacting with Several Growth Factors in an Oligomerization-dependent Manner*
  • Yu Wang, K. Lam, +4 authors A. Xu
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 6 May 2005
TLDR
The data collectively suggest that the oligomeric complexes of adiponectin can modulate the biological actions of several growth factors by controlling their bioavailability at a pre-receptor level and that this effect might partly account for the anti-atherogenic, anti-angiogenic, and anti-proliferative functions of adip onectin. Expand
Post-translational Modifications of the Four Conserved Lysine Residues within the Collagenous Domain of Adiponectin Are Required for the Formation of Its High Molecular Weight Oligomeric Complex*
  • Yu Wang, K. Lam, +7 authors A. Xu
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 16 June 2006
TLDR
Hydroxylation and glycosylation of the lysine residues within the collagenous domain of adiponectin are critically involved in regulating the formation of its HMW oligomeric complex and consequently contribute to the insulin-sensitizing activity of adip onectin in hepatocytes. Expand
Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease.
  • G. Cooper
  • Biology, Medicine
  • Endocrine reviews
  • 1 April 1994
TLDR
Amylin is the major protein in islet amyloid, extracellular accumulation of which occurs in most patients with non-insulin-dependent diabetes mellitus (NIDDM) and increases in extent with duration in this disease. Expand
Watching amyloid fibrils grow by time-lapse atomic force microscopy.
TLDR
The ability of AFM to continuously monitor growth, directionality, and changes in morphology for individual fibrils, provides a significant advantage over spectroscopy-based bulk methods which average the growth of many fibrili and typically require 100 to 1000-fold more protein. Expand
Randomized controlled crossover study of the effect of a highly beta-glucan-enriched barley on cardiovascular disease risk factors in mildly hypercholesterolemic men.
TLDR
The effect of beta-glucan-enriched barley on lipid profile was highly variable between subjects, and there was no evidence of a clinically significant improvement in CVD risk across this group of mildly hyperlipidemic men. Expand
Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.
TLDR
The impaired insulin secretion in Type 2 diabetes may be due to a decrease in B-cells and to disruption of the islet structure by amyloid, and the increase in A-cells may contribute to the hyperglucagonaemia and hyperglycaemia of Type 2 Diabetes. Expand
Polymorphic fibrillar assembly of human amylin.
TLDR
Similarities exist between amylin fibrils and those formed from other amyloid proteins, suggesting that the in vitro assembly of synthetic protein may serve as a useful model system in advancing the understanding of amyloids formation in disease. Expand
Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.
TLDR
The results showed that adiponectin significantly attenuated the proliferations of two typical human breast cancer cells, MDA-MB-231 and T47D, in a cell type-specific manner, and suggested that adip onectin might represent a novel therapeutic target for this disease. Expand
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