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WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification
It is proposed that WLS binds Wnts in part through a lipid-binding domain, and that vacuolar acidification is required to release palmitoylated WNT3A from WLS in secretory vesicles, possibly to facilitate transfer of Wnt3A to a soluble carrier protein.
Possible Loss of the Chloroplast Genome in the Parasitic Flowering Plant Rafflesia lagascae (Rafflesiaceae)
The inability to identify substantial plastid genome sequences from R. lagascae using multiple approaches suggests that the parasitic plant genus Rafflesia may be the first plant group for which there is no recognizable plastids genome, or if present is found in cryptic form at very low levels.
Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.
- D. Taşdemir, G. C. Mangalindan, C. Ireland
- Chemistry, BiologyJournal of natural products
- 26 January 2002
Two new isomalabaricane triterpenes have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines and showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor cells.
A bacterial source for mollusk pyrone polyketides.
Comparison of the Venom Peptides and Their Expression in Closely Related Conus Species: Insights into Adaptive Post-speciation Evolution of Conus Exogenomes
Comparison of the sequences and expression levels of conotoxins from several specimens of two closely related worm-hunting species, Conus tribblei and Conus lenavati, were compared through transcriptome analysis and revealed each specimen produces a distinct set of highly expressed conopeptides, reflecting the capability of individual snails to fine-tune the composition of their venoms.
Pseudovibrio denitrificans strain Z143-1, a heptylprodigiosin-producing bacterium isolated from a Philippine tunicate.
- Alice A Sertan-de Guzman, Rey Z Predicala, G. Concepcion
- BiologyFEMS microbiology letters
- 1 December 2007
While there is no report of a secondary metabolite for Pseudovibrio denitrificans, Z143-1 produces the red pigment heptylprodigiosin, also known as 16-methyl-15-heptyl-prodiginine, which shows anti-Staphylococcus aureus activity.
Microbial Distribution and Abundance in the Digestive System of Five Shipworm Species (Bivalvia: Teredinidae)
Examination of the digestive microbiota of 5 shipworm species reveals that the caecum, a large sac-like appendage of the stomach that typically contains large quantities of wood particles and is considered the primary site of wood digestion, harbors only very sparse microbial populations, and suggests that due to low abundance, bacteria in the caeca may contribute little to lignocellulose degradation.
Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.
Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were identified as active constituents and their structures were elucidated through analysis of NMR data and a detailed analysis of pseudo MS(3) spectra.
Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp
A novel lumun-lumun sampling methodology was used to obtain a large diversity of micromollusks, including the new species Lienardia totopotens, providing a possible basis to synthesize more selective derivatives.
Cytotoxic Bromoindole Derivatives and Terpenes from the Philippine Marine Sponge Smenospongia sp.
- D. Taşdemir, T. Bugni, G. C. Mangalindan, G. Concepcion, M. K. Harper, C. Ireland
- ChemistryZeitschrift fur Naturforschung. C, Journal of…
- 1 September 2002
The furanosesterterpene furospinulosin 1 (8) was obtained for the first time from the genus Smenospongia and the cytotoxic potential of 1−8 was evaluated in a panel of isogenic HCT-116 human colon tumor cell lines.