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Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior
It is reported that dopamine D2/D3 agonists elicit dose-dependent yawning behavior in rats, resulting in an inverted U-shaped dose-response curve.
Nicotine-like behavioral effects of the minor tobacco alkaloids nornicotine, anabasine, and anatabine in male rodents.
Results suggest that the minor tobacco alkaloids may substitute for the subjective effects of nicotine and attenuate withdrawal and craving without the abuse liability of nicotine.
Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists
D3 and D2 receptors have specific roles in the mediation of yawning and hypothermia, respectively, and the analysis of these effects allow inferences to be made regarding the selectivity of D2/D3 agonists and antagonists with respect to their actions at D2 and D3 receptors.
Food Restriction Alters N′-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (Pramipexole)-Induced Yawning, Hypothermia, and Locomotor Activity in Rats: Evidence for Sensitization of
Food restriction enhances sensitivity to the reinforcing effects of a variety of drugs of abuse including opiates, nicotine, and psychostimulants. Food restriction has also been shown to alter a
Proerectile Effects of Dopamine D2-Like Agonists Are Mediated by the D3 Receptor in Rats and Mice
Support is provided that D2-like agonist-induced PE and yawning are differentially mediated by the D3 (induction) and D2 (inhibition) receptors, and that apomorphine was equipotent at inducing PE in wild-type and D4RKO mice.
Lorcaserin Reduces the Discriminative Stimulus and Reinforcing Effects of Cocaine in Rhesus Monkeys
Results show that lorcaserin attenuates the discriminative stimulus effects of cocaine after acute administration and the reinforcing effects of Cocaine after acute and repeated administration, consistent with the view that it might have utility in treating cocaine abuse.
Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats
Yawning was reliably produced in rats, and by the cholinergic agonist, physostigmine, in both the species, however, DA agonists were ineffective in producing yawning in Swiss–Webster or DA D2R and DA D3R knockout or wild-type mice.
Effects of consuming a diet high in fat and/or sugar on the locomotor effects of acute and repeated cocaine in male and female C57BL/6J mice.
Evidence that consuming a diet high in fat and/or sugar enhances abuse-related effects of cocaine in ways that might increase vulnerability to abuse cocaine is provided and a potentially important sex-related difference in the interaction between nutrition and cocaine effects is identified, with the impacts of sucrose consumption being greater in females than in males.
Drug and Reinforcement History as Determinants of the Response-Maintaining Effects of Quinpirole in the Rat
  • G. Collins, J. Woods
  • Biology, Psychology
    Journal of Pharmacology and Experimental…
  • 1 November 2007
The behavioral effects of quinpirole under these situations represent a novel constellation of actions relative to other drug reinforcers, and they suggest that the direct effects of self-administered quinPirole may be important in establishing the response-maintained effects.
The abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter
These synthetic cathinones were more effective reinforcers than cocaine, and the measures of reinforcing effectiveness determined by PR and demand curve analyses were highly correlated with selectivity for DAT over SERT.