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The Drosophila melanogaster homologue of an insect calcitonin-like diuretic peptide stimulates V-ATPase activity in fruit fly Malpighian tubules.
- G. Coast, S. Webster, K. Schegg, S. Tobe, D. Schooley
- BiologyThe Journal of experimental biology
- 15 May 2001
The Droseophila melanogaster homologue of an insect calcitonin-like diuretic hormone was identified in a BLAST search of the Drosophila genome database and the predicted 31-residue amidated peptide was synthesised and tested for activity on fruit fly Malpighian tubules.
Cockroach diuretic hormones: characterization of a calcitonin-like peptide in insects.
- K. Furuya, R. J. Milchak, D. Schooley
- BiologyProceedings of the National Academy of Sciences…
- 6 June 2000
Dippu-DH(31) represents a distinct type of insect DH with actions that differ from those of previously identified insect peptides with diuretic activity.
Mosquito natriuretic peptide identified as a calcitonin-like diuretic hormone in Anopheles gambiae (Giles)
- G. Coast, C. Garside, S. Webster, K. Schegg, D. Schooley
- Biology, MedicineJournal of Experimental Biology
- 1 September 2005
The CT-like peptide Anoga-DH31 is the previously uncharacterised mosquito natriuretic peptide, which acts via cyclic AMP to stimulate secretion of Na+-rich urine by opening a Na+ conductance in the basolateral membrane of Malpighian tubule principal cells.
Expression and Functional Characterization of aDrosophila Neuropeptide Precursor with Homology to Mammalian Preprotachykinin A*
Analysis of the Drosophila genome allowed us to identify a putative tachykinin-related peptide prohormone (prepro-DTK) gene, which encodes five novel D rosophila tachyKinin- related peptides (called DTK peptides) with conserved C-terminal FXGXR-amide motifs common to other insect tachy Kinin-based peptides.
Insect diuretic and antidiuretic hormones
The diuretic activity of a series of cephalomyotropic neuropeptides, the achetakinins, on isolated Malpighian tubules of the house cricket, Acheta domesticus
Fluid secretion by single isolated Malpighian tubules of the house cricket, Acheta domesticus, and their response to diuretic hormone
- G. Coast
- 1 December 1988
A simple modification of the Ramsay method is described for the isolation in vitro of Malpighian tubules from Acheta domesticus using a simple Ringer solution.
Toward a consensus nomenclature for insect neuropeptides and peptide hormones
Neuroendocrine control of ionic homeostasis in blood-sucking insects
- G. Coast
- Medicine, BiologyJournal of Experimental Biology
- 1 February 2009
Primary urine is voided virtually unchanged during the rapid diuresis that follows a blood meal, and neurohormones acting on the Malpighian tubules have a dominant role in the control of ionic homeostasis.