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Corticotropin releasing hormone inhibits an inwardly rectifying potassium current in rat corticotropes
- Y. A. Kuryshev, L. Haak, G. Childs, A. K. Ritchie
- Chemistry, Medicine
- The Journal of physiology
- 1 July 1997
1 The perforated‐patch‐clamp technique was used to identify an inwardly rectifying K+ current (IK(IR)) in cultured rat anterior pituitary cells highly enriched in corticotropes. IK(IR) was rapidly… Expand
Corticotropin-releasing hormone stimulation of Ca2+ entry in corticotropes is partially dependent on protein kinase A.
The modulation of membrane excitability and cytosolic Ca2+ levels by corticotropin-releasing hormone (CRH), (Bu)2cAMP (dBcAMP), and forskolin was examined in enriched populations of cultured rat… Expand
Epidermal growth factor and transforming growth factor-alpha messenger ribonucleic acids and their receptors in the rat anterior pituitary: localization and regulation.
Evidence has shown that epidermal growth factor (EGF), transforming growth factor-alpha (TGF alpha) and their receptors (EGF receptors) are present in the anterior pituitary, indicating that the… Expand
Application of the avidin-biotin-peroxidase complex (ABC) method to the light microscopic localization of pituitary hormones.
The avidin-biotin-peroxidase complex (ABC) method was applied to semithin (0.5-1 micron) plastic-embedded sections of intact male rat pituitaries with the use of techniques previously developed for… Expand
Cytological factors that support nonparallel secretion of luteinizing hormone and follicle-stimulating hormone during the estrous cycle.
Gonadotropes from cycling female rats were studied to investigate possible mechanisms for the nonparallel release of LH and FSH. The percentages of total gonadotropes increased from 14% during estrus… Expand
Differential expression of growth hormone messenger ribonucleic acid by somatotropes and gonadotropes in male and cycling female rats.
Past studies have reported the appearance of cells sharing phenotypic characteristics of gonadotropes and GH cells. During diestrus and early proestrus, a subset of somatotropes (40-60%) expressed… Expand
Differential storage and release of luteinizing hormone and follicle-releasing hormone from individual gonadotropes separated by centrifugal elutriation.
Two subtypes of pituitary gonadotropes are known to exist: monohormonal and multihormonal. When separated by centrifugal elutriation monohormonal cells are found in the small fractions whereas… Expand
Storage of anterior lobe adrenocorticotropin in corticotropes and a subpopulation of gonadotropes during the stress-nonresponsive period in the neonatal male rat.
The neonatal rat exhibits a stress-nonresponsive period during days 4-11 of postnatal development. The role and response of the anterior lobe corticotrope was studied with immunocytochemical stains… Expand
Corticotropin-releasing hormone stimulates Ca2+ entry through L- and P-type Ca2+ channels in rat corticotropes.
CRH induces corticotrope membrane depolarization and facilitates action potential firing. The increase in electrical excitability causes large oscillatory increases in cytosolic Ca2+ levels. In this… Expand
Cells that express luteinizing hormone (LH) and follicle-stimulating hormone (FSH) beta-subunit messenger ribonucleic acids during the estrous cycle: the major contributors contain LH beta, FSH beta,…
There is a 2-fold increase in the percentage of gonadotropes bearing LH beta or FSH beta mRNAs or antigens as the cells approach proestrus. The purpose of this study was to identify the source of… Expand